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FLASH GENE
Symbol METTL1 contributors: mct/npt - updated : 09-11-2009
HGNC name methyltransferase-like 1
HGNC id 7030
Location 12q14.1      Physical location : 58.162.351 - 58.165.914
Synonym name
  • tRNA(m7G46)-methyltransferase
  • D1075-like gene product
  • Synonym symbol(s) C12orf1, YDL201W, TRM8, FLJ95748
    EC.number 2.1.1.33
    DNA
    TYPE functioning gene
    STRUCTURE 4.08 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    INHBC 12q13.1 inhibin, beta C INHBE 12q13.2 inhibin, beta E GLI 12q13.3-q14.1 glioma-associated oncogene homolog (zinc finger protein) ARHGAP9 12q14 Rho GTPase activating protein 9 MARS 12q13.11-q14.3 methionine-tRNA synthetase DDIT3 12q13.1-q13.2 DNA-damage-inducible transcript 3 MBD6 12q13.2 methyl-CpG binding domain protein 6 DCTN2 12q13.2-q13.3 dynactin 2 (p50) KIF5A 12q13 kinesin family member 5A PIP5K2C 12q13.2 phosphatidylinositol-4-phosphate 5-kinase, type II, gamma FLJ34766 GEFT 12q13.2 RAC/CDC42 exchange factor SLC26A10 12q13 solute carrier family 26, member 10 GALGT 12q13.3 UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase (GalNAc-T) LOC390333 12 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein OS-9 12q13 amplified in osteosarcoma CENTG1 12q13.3 centaurin, gamma 1 SAS 12q13-q14 sarcoma amplified sequence CDK4 12q14 cyclin-dependent kinase 4 LOC92979 12q13.2 hypothetical protein BC009489 CYP27B1 12q13-q14 cytochrome P450, family 27, subfamily B, polypeptide 1 METTL1 12q13 methyltransferase-like 1 DKFZP586D0919 12q13.2 hepatocellularcarcinoma-associated antigen HCA557a TSFM 12q13-q14 Ts translation elongation factor, mitochondrial AVIL 12q13.13 advillin CTDSP2 12q13-q15 . CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 KUB3 12q13.2 Ku70-binding protein 3 LOC338805 12q13.2 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein
    RNA
    TRANSCRIPTS type messenger
    text alternative splice variants encoding different protein isoforms and transcript variants utilizing alternative polyA sites have been described in the literature
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 1311 31.5 276 - Bahr (1999)
    lacking exon 2
    - splicing 1594 - 36 - Bahr
  • truncated form (exon 1)
  • containing exon 2 which results in premature termination
  • 5 splicing 1126 17.4 155 - Bahr (1999)
  • truncated
  • lacking exons 2 and 4 which disrupts the reading frame
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Digestiveliver    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved S-adenosylmethionine-binding motif (Alexandrov 2002)
  • HOMOLOGY
    interspecies ortholog to yeast S. cerevisiae YDL201w
    ortholog to murine Mettl1
    homolog to Drosophila EG:22E5.4
    homolog to C.elegans W02B12.10
    Homologene
    FAMILY
  • methyltransferase superfamily
  • TrmB family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • methyltransferase activity
  • required for tRNA 7-methylguanosine-methyltransferase activity (Alexandrov 2002)
  • catalyses the 7-methylguanosine modification of tRNA (Cartlidge 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • form a complex with WDR4 (Alexandrov 2002)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other inactivated by AKT1 and RPS6KA1 (Cartlidge 2005)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS