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FLASH GENE

Symbol

METTL1

contributors: mct/npt - updated : 05-11-2019

HGNC name	methyltransferase-like 1
HGNC id	7030

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q14.1      Physical location : 58.162.351 - 58.165.914
Synonym name	tRNA(m7G46)-methyltransferase
	D1075-like gene product
Synonym symbol(s)	C12orf1, YDL201W, TRM8, FLJ95748, TRMT8, FLJ95748
EC.number	2.1.1.33

DNA

TYPE	functioning gene
STRUCTURE	4.08 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	alternative splice variants encoding different protein isoforms and transcript variants utilizing alternative polyA sites have been described in the literature

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005371 6 splicing 1311 NP_005362 31.5 276 - 2005 15861136 lacking exon 2 variant 2 - splicing 1594 isoform 2 - 36 - 2005 15861136 truncated form (exon 1) containing exon 2 which results in premature termination NM_023033 5 splicing 1193 NP_075422 17.4 155 - 2005 15861136 truncated lacking exons 2 and 4 which disrupts the reading frame

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Cardiovascular heart         Digestive liver         Nervous brain         Reproductive male system prostate       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a conserved S-adenosylmethionine-binding motif (Alexandrov 2002)

HOMOLOGY

interspecies	ortholog to yeast S. cerevisiae YDL201w
	ortholog to murine Mettl1
	homolog to Drosophila EG:22E5.4
	homolog to C.elegans W02B12.10
	ortholog to yeast Trm8

Homologene

FAMILY	methyltransferase superfamily
	TrmB family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm

basic FUNCTION	methyltransferase activity
	required for tRNA 7-methylguanosine-methyltransferase activity (Alexandrov 2002)
	catalyses the 7-methylguanosine modification of tRNA (Cartlidge 2005)
	NSUN2 and METTL1, are required for protecting tRNA against tRNA decay (RTD)
	METTL1 promotes cell proliferation and migration in hepatocellular carcinoma (HCC, and exerts oncogenic activities via suppression of PTEN signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

form a complex with WDR4 (Alexandrov 2002)

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

inactivated by AKT1 and RPS6KA1 (Cartlidge 2005)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in hepatocellular carcinoma (HCC) and exhibits oncogenic activities via PTEN/AKT1 signaling pathway

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	serves as a promising prognostic biomarker in hepatocellular carcinoma (HCC)
Therapy target
	System Type Disorder Pubmed cancer digestive liver METTL1/PTEN axis may provide therapeutic potential in HCC intervention

ANIMAL & CELL MODELS