Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol METAP2 contributors: - updated : 21-04-2006
HGNC name methionyl aminopeptidase 2
HGNC id 16672
Location 12q22-q23.2      Physical location : 95.867.821 - 95.909.611
Synonym name methionine aminopeptidase, eIF-2-associated p67
Synonym symbol(s) MNPEP
EC.number 3.4.11.18
DNA
TYPE functioning gene
STRUCTURE 39.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC341444 12q22 similar to alpha NAC/1.9.2. protein LOC387873 12 LOC387873 NUDT4 12q21 nudix (nucleoside diphosphate linked moiety X)-type motif 4 UBE2N 12q21.33 ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) MRPL42 12q22 mitochondrial ribosomal protein L42 SOCS2 12q21.3-q23 suppressor of cytokine signaling 2 LOC144483 12q22 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) CRADD 12q21.33-q23.1 CASP2 and RIPK1 domain containing adaptor with death domain PLXNC1 12q23.3 plexin C1 NY-REN-58 12q22 NY-REN-58 antigen LOC387874 12 hypothetical gene supported by NM_014886 LOC283398 12q22 similar to Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor (Succinyl-CoA synthetase, betaG chain) (SCS-betaG) (GTP-specific succinyl-CoA synthetase beta subunit) KIAA1145 12q22 KIAA1145 protein DAP13 12q23.1 13kDa differentiation-associated protein NR2C1 12q22 nuclear receptor subfamily 2, group C, member 1 FGD6 12q23.1 FYVE, RhoGEF and PH domain containing 6 VEZATIN 12q21.33 FYVE, RhoGEF and PH domain containing 6 LOC387875 12 LOC387875 LOC283412 12q23.1 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) METAP2 12q22 methionyl aminopeptidase 2 USP44 12q21.33 ubiquitin specific protease 44 NTN4 12q22-q23 netrin 4 SNRPF 12q21.33 small nuclear ribonucleoprotein polypeptide F FLJ40089 12q23.1 hypothetical protein FLJ40089 MGC35366 12q23.1 hypothetical protein MGC35366 HAL 12q22-q23.1 histidine ammonia-lyase LTA4H 12q22 leukotriene A4 hydrolase ELK3 12q22-q23.1 ELK3, ETS-domain protein (SRF accessory protein 2) PCTK2 12q23.1 PCTAIRE protein kinase 2 FLJ31514 12q23.1 hypothetical protein FLJ31514 FLJ44112 12q23.1 FLJ44112 protein LOC387876 12 LOC387876 LOC390352 12 similar to eukaryotic translation elongation factor 1 alpha 1; CTCL tumor antigen; translation elongation factor 1 alpha 1-like 14; prostate tumor-inducing protein 1; EF1a-like protein; glucocorticoid receptor AF-1 specific elongati NEDD1 12q22 neural precursor cell expressed, developmentally down-regulated 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveesophagus   highly
 liver    
Hearing/Equilibriumear   highly
Lymphoid/Immunelymph node   highly
Nervousbrain    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage germ cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal extended strings of basic and acidic residues
  • a C terminal catalytic domain
  • HOMOLOGY
    interspecies homolog to rattus P67 translational initiation factor
    Homologene
    FAMILY peptidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • protecting the alpha subunit of eIF from inhibitory phosphorylation
  • removing the N-terminal MET residue from nascent proteins
  • playing a pivotal role in cell growth
  • CELLULAR PROCESS cell life, antiapoptosis
    protein, post translation
    protein, degradation
    protein, translation regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    cobalt Co2+
    protein
    cell & other
    REGULATION
    Other regulated by S100A4
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene target for cancer therapy through reversible METAP2 inhibitors
    Marker
    Therapy target
    ANIMAL & CELL MODELS