Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MEPE contributors: mct/npt - updated : 20/12/2008
HGNC name matrix, extracellular phosphoglycoprotein with ASARM motif (bone)
HGNC id 13361
Location 4q21.1      Physical location : 88.742.562 - 88.767.966
Synonym name
  • tumor-secreted protein in oncogenic hypophosphatemic osteomalacia
  • matrix, extracellular phosphoglycoprotein with ASARM motif (bone)
  • osteoblast/osteocyte factor 45
  • Synonym symbol(s) OF45
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text SIBLINGs share many common features, such as their tandem gene location
    STRUCTURE 13.80 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - BMP3 - MEPE - D4S1534 - DMP1 - ANXA3 - DSPP - IBSP - SPP1 - BMPR1B - qter
    Authors Rowe (00)
    regionally located cluster of bone-tooth mineral genes
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1979 - 525 - Ogbureke (2004)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   lowly
     tooth    
    Nervousbrain    
    Urinarykidneytubuleconvoluted tubuledistal tubulelowly
     kidneytubuleconvoluted tubuleproximal tubulelowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skeletonosteoblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • multiple phosphorylation sites
  • disulfide-free flexible hydrophilic structures
  • presence of the integrin-binding tripeptide, arginine-glycine-aspartate (RGD)
  • a C terminal ASARM, (DSPP/OPN/DMP1) acidic serine-aspartate rich motif
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Mepe
    intraspecies homolog to other bone-tooth mineral matrix phospho-glycoproteins
    Homologene
    FAMILY
  • Small Integrin Binding Ligand N-linked Glycoprotein (SIBLING) family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in phosphate and bone metabolism
  • may be having a role as an early regulator of odontogenic differentiation
  • by direct interaction, decreases CHEK1 from ubiquitin-mediated proteolysis and thus protects cells from DNA damage induced killing (Liu 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text bone mineralization
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • integrin receptor(s)
  • interacting with CHEK1 (Liu 2009)
  • DSPP, MEPE, VCAN, OGN play complementary roles during odontogenesis
  • cell & other
    REGULATION
    Other downregulated by 1.25 (OH)2D3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oncogenic hypophosphatemic osteomalacia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS