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FLASH GENE
Symbol MEP1A contributors: - updated : 27-10-2005
HGNC name meprin A, alpha (PABA peptide hydrolase)
HGNC id 7015
Location 6p21.2-p21.1      Physical location : 46.761.093 - 46.807.519
Synonym name zinc metalloendopeptidase 1, alpha subunit
Synonym symbol(s) PPHA
EC.number 3.4.24.18
DNA
TYPE functioning gene
STRUCTURE 46.00 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map see PKHD1
Physical map
SUPT3H 6p21.3-p21.1 suppressor of Ty 3 homolog (S. cerevisiae) RUNX2 6p21 runt-related transcription factor 2 CLIC5 6p12.1-21.1 chloride intracellular channel 5 ENPP4 6p21.1-p11.2 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative function) ENPP5 6p21.1-p11.2 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative function) ACTGP9 6p21.1 actin, gamma pseudogene 9 DSCR1L1 6p21-p11 Down syndrome critical region gene 1-like 1 LOC340211 6p21.1 similar to LINE-1 REVERSE TRANSCRIPTASE HOMOLOG CYP39A1 6p21.1-p11.2 cytochrome P450, family 39, subfamily A, polypeptide 1 SLC25A27 6p12.3 solute carrier family 25, member 27 TDRD6 6p21.1 tudor domain containing 6 PLA2G7 6p21.2-p12 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) LOC389394 6 similar to hypothetical protein DKFZp434D2328 MEP1A 6p21.2-p21.1 meprin A, alpha (PABA peptide hydrolase) GPR116 6p12.3 G protein-coupled receptor 116 GPR110 6p21.1 G protein-coupled receptor 110 FLJ22684 6p21.1 hypothetical protein FLJ22684 TNFRSF21 6p21.1-12.2 tumor necrosis factor receptor superfamily, member 21 CD2AP 6p12 CD2-associated protein GPR111 6p12.3 G protein-coupled receptor 111 GPR115 6p12.3 G protein-coupled receptor 115 C6orf138 6p12.3 chromosome 6 open reading frame 138 LOC389395 6 similar to heterogeneous nuclear ribonucleoprotein A3 RBMXP1 6p12.3 RNA binding motif protein, X chromosome pseudogene 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 intestinelarge intestinecolon  
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Epithelial    
Membranemucouslamina propriaintestine villi 
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide,
  • a propeptide,
  • a protease domain containing an astacin signature,
  • a meprin A-5 protein tyrosine phosphatase mu(MAM),
  • a meprin and TRAF homology (MATH)domain,
  • an after MATH (AM) domain,
  • an EGF like domain,
  • a putative transmembrane segment (1TM)
  • a short cytoplasmic tail
  • conjugated GlycoP
    mono polymer homomer , heteromer , oligo
    HOMOLOGY
    Homologene
    FAMILY astacin family of zinc metalloendopeptidases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text secreted forms
    basic FUNCTION hydrolysing basement membrane components such as collagen IV, nidogen-1 and fibronectin
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component associating with MEP1B
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS