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FLASH GENE
Symbol MEOX2 contributors: mct - updated : 22-01-2011
HGNC name mesenchyme homeobox 2
HGNC id 7014
Location 7p21.2      Physical location : 15.650.838 - 15.726.308
Synonym name
  • mesenchyme homeo box 2 (growth arrest-specific homeo box)
  • growth arrest-specific homeobox
  • homeobox protein MOX-2
  • Synonym symbol(s) GAX, MOX2
    DNA
    TYPE functioning gene
    STRUCTURE 75.47 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure a CAX trinucleotide repeat
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392636 7 similar to RIKEN cDNA A530016O06 gene TFEC 7q31.2 transcription factor EC LOC392745 7 similar to Six transmembrane epithelial antigen of prostate MEOX2 7p21 mesenchyme homeo box 2 (growth arrest-specific homeo box) STEAP2 7q21 six transmembrane epithelial antigen of prostate 2 LOC389466 7 LOC389466 FLJ21062 7q21.2 hypothetical protein FLJ21062 LOC221813 7p21.3 similar to RIKEN cDNA A530016O06 gene LOC85865 7q21.2 hypothetical protein BC004923 CLDN12 7q21 claudin 12 TES 7q31.2 testis derived transcript (3 LIM domains) MEOX2 7p21 mesenchyme homeo box 2 (growth arrest-specific homeo box) CAV2 7q31.1-q31.2 caveolin 2 PFTK1 7q21-q13 PFTAIRE protein kinase 1 CAV1 7q31.2-q31.3 caveolin 1, caveolae protein, 22kDa LOC392637 7 similar to RIKEN cDNA 4930579E17 MET 7q31.2-q31.3 met proto-oncogene (hepatocyte growth factor receptor) SOSTDC1 7p21.2 sclerostin domain containing 1 LOC392638 7 similar to RIKEN cDNA 4933421E18 CAPZA2 7q31.2-q31.3 capping protein (actin filament) muscle Z-line, alpha 2 LOC346380 7p21.2 similar to ataxin 2 related protein isoform D; ataxin-2 domain protein DKFZP564O043 7p21 hypothetical protein DKFZp564O043 ST7 7q31.1-q31.3 suppression of tumorigenicity 7 LOC389467 7 similar to RIKEN cDNA 4930579E17 BZW2 7p21.3 basic leucine zipper and W2 domains 2 FZD1 7q21 frizzled homolog 1 (Drosophila) TM4SF13 7p21.1 transmembrane 4 superfamily member 13 AGR2 7p21.3 anterior gradient 2 homolog (Xenepus laevis) LOC392746 7 LOC392746 SOSTDC1 7p21.2 sclerostin domain containing 1 BCMP11 7p21.2 breast cancer membrane protein 11 LOC389468 7 similar to RIKEN cDNA 4933421E18 WNT2 7q31 wingless-type MMTV integration site family member 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2383 - 304 - 2005 16335786
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousnervecranial nerve  highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text
  • likely, in developing somites and sclerotomal derivatives,
  • in extra-embryonic tissues such as placenta, in the cytotrophoblast cell layer
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helix-turn-helix, DNA binding domain
  • HOMOLOGY
    interspecies homolog to murine Mox2
    Homologene
    FAMILY
  • homeobox proteins family
  • CATEGORY transcription factor , signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • colocalized to the nuclear fraction, with IKBKB and RELA
  • basic FUNCTION
  • important regulator of vertebrate limb myogenesis, and of vascular differentiation
  • involved in regulating epithelial-mesenchymal cell interactions in extraembryonic tissues
  • activates CDKN1A through multiple upstream AT-rich sequences
  • regulate endothelial cell proliferation and muscle development
  • primarily involved in the TGF-beta tumor suppressor pathway
  • with SOSTDC1, may have a role in the progression of Wilms tumorigenesis
  • homeoprotein which inhibits nuclear factor-kappaB (NF-kappaB) signalling and endothelial cells activation in response to serum and proangiogenic factors
  • modulates the activity of the RELA complex through direct interaction with its components
  • an important regulator of vascular cell proliferation and is a direct transcriptional activator of both CDKN1A and CDKN2A
  • MEOX1 and MEOX2 have been shown to be partially functionally redundant during development, suggesting that they regulate similar target genes
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • can form protein complexes with Smads leading to cooperative regulation of CDKN1A gene expression
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • activating MLLT7
  • interacting with RING finger protein 10 (RNF10)
  • interacts with components of this pathway in vascular ECs (endothelial cells)to modulate NF-kappaB activity and EC activation
  • cell & other
    REGULATION
    activated by MIR221 that upregulates MEOX2 primarily through its ability to downregulate the expression of ZEB2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Alzheimer disease, by blood vessels dysregulation in the brain
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target therapeutic approach in Alzheimer disease (based on reversing the downregulation of MEOX2)
    SystemTypeDisorderPubmed
    cancerangiogenesis 
    respiratorylung 
    ANIMAL & CELL MODELS