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FLASH GENE
Symbol MEOX1 contributors: mct/npt/pgu - updated : 15-02-2013
HGNC name mesenchyme homeobox 1
HGNC id 7013
Corresponding disease
KFS2 Klippel-Feil syndrome
Location 17q21.31      Physical location : 41.717.766 - 41.739.262
Synonym name mesenchyme homeo box 1
Synonym symbol(s) MOX1, MOX-1
DNA
TYPE functioning gene
STRUCTURE 21.51 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see BRCA1 BRCA1
Physical map
PSME3 17q21 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) AOC2 17q21 amine oxidase, copper containing 2 (retina-specific) AOC3 17q21 amine oxidase, copper containing 3 (vascular adhesion protein 1) LOC90586 17q21.31 amine oxidase pseudogene LOC388387 17 hypothetical gene supported by AK055784 G6PC 17q21 glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease) MGC2744 17q21.31 hypothetical protein MGC2744 DKFZp761H0421 17q21.31 hypothetical protein DKFZp761H0421 RPL27 17q21 ribosomal protein L27 IFI35 17q21 interferon-induced protein 35 VAT1 17q21 vesicle amine transport protein 1 homolog (T californica) ARHN 17q21 ras homolog gene family, member N BRCA1 17q21 breast cancer 1, early onset RPL21P4 17q21 ribosomal protein L21 pseudogene 4 NBR2 17q21 neighbor of BRCA1 gene 2 LOC387620 17 membrane component, chromosome 17, surface marker 2 MGC20235 17q21.31 hypothetical protein MGC20235 LOC388388 17 LOC388388 RNU2P2 17q21.31 RNA, U2 small nuclear pseudogene 2 ARF4L 17q12-q21 ADP-ribosylation factor 4-like LOC284064 17q21.31 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) DHX8 17q21.31 DEAH (Asp-Glu-Ala-His) box polypeptide 8 ETV4 17q21 ets variant gene 4 (E1A enhancer binding protein, E1AF) MEOX1 17q21 mesenchyme homeo box 1 LOC390797 17 similar to WHSC1L1 protein isoform long; Wolf-Hirschhorn syndrome candidate 1-like 1 protein SOST 17q12-q21 sclerosteosis DUSP3 17q21 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) LOC284067 17q21.31 hypothetical LOC284067 MPP3 17q12-q21 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) TREM4 17q21.31 triggering receptor expressed on myeloid cells 4 MPP2 17q12-q21 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) APR-2 17q21.31 apoptosis related protein LOC390798 17 similar to wingless-type MMTV integration site family, member 9B precursor; wingless-type MMTV integration site family, member 15 PPY 17q21.2 pancreatic polypeptide PYY 17q21.1 peptide YY NAGS 17q21.31 peptide YY MGC4251 17q21.31 hypothetical protein MGC4251 FLJ30656 17q21.31 hypothetical protein FLJ30656 G6PC3 17q21.31 glucose-6-phosphatase catalytic subunit 3 HDAC5 17q21 histone deacetylase 5 MGC3130 17q21.31 hypothetical protein MGC3130 ASB16 17q21.31 ankyrin repeat and SOCS box-containing 16 DKFZp762C2414 17q21.31 hypothetical protein DKFZp762C2414 MGC3123 17q21.31 hypothetical protein MGC3123 UBTF 17q21.3 upstream binding transcription factor, RNA polymerase I LOC390799 17 similar to SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1 SLC4A1 17q21-q22 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 splicing 2330 - 254 - 1997 9373945
2 splicing 2150 - 184 - 1997 9373945
lacking exon 2
4 - 2184 - 139 - 1997 9373945
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text restricted exclusively to follicular cells in the innermost layer of the outer root sheath by 21 weeks of development
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix, homeobox DNA binding domain
  • HOMOLOGY
    interspecies ortholog to murine Meox1
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation
  • activating NKX3-2 (activates the NKX3-2 promoter in a dose-dependent manner and this activity is enhanced in the presence of PAX11 and/or PAX9)
  • required for NKX3-2 expression in the sclerotome
  • play role with GLI2 in the commitment of cells to the skeletal muscle lineage
  • part of a regulatory circuit that serves an essential, non-redundant function in the maintenance of rostro-caudal sclerotome polarity and axial skeleton formation
  • MEOX1 can specifically bind the DNA sequences recognized by HOXA2 on its functional target genes
  • MEOX1 and MEOX2 have been shown to be partially functionally redundant during development, suggesting that they regulate similar target genes
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • regulates the MEOX2 target genes CDKN1A and CDKN2A
  • cell & other
    REGULATION
    Other regulated by a regulatory loop between GLI2, MEOX1, and PAX3 that is essential for specification of mesodermal cells into the muscle lineage
    ASSOCIATED DISORDERS
    corresponding disease(s) KFS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS