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FLASH GENE
Symbol MEMO1 contributors: mct - updated : 25-09-2012
HGNC name mediator of cell motility 1
HGNC id 14014
Location 2p23.1      Physical location : 32.092.895 - 32.235.698
Synonym name
  • chromosome 2 open reading frame 4
  • mediator of ErbB2-driven cell motility 1
  • hepatitis C virus NS5A-transactivated protein 7
  • HCV NS5A-transactivated protein 7
  • protein memo
  • C21orf19-like protein
  • Synonym symbol(s) CGI-27, NS5ATP7, C2orf4, MEMO, DKFZp434I0135, FLJ25031, C21orf19-like
    DNA
    TYPE functioning gene
    STRUCTURE 142.81 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 1831 33 297 - 2008 18045866
  • C2orf4a
  • - splicing 1522 - 300 - 2008 18045866
    8 - 1762 - 274 - 2008 18045866
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Reproductivemale systemtestis  moderately
    Respiratoryrespiratory tractlarynx  predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a phosphotyrosine motif for binding with ERBB2
  • HOMOLOGY
    Homologene
    FAMILY
  • UPF0103 family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton
  • represents a new class of phosphotyrosine-binding protein
  • effector of the ERBB2 receptor tyrosine kinase involved in breast carcinoma cell migration
  • required for the localization of the RHOA guanosine triphosphatase and its effector DIAPH1 to the plasma membrane
  • controls ERBB2-regulated microtubules dynamics by altering the transition frequency between microtubules growth and shortening phases
  • also regulates actin dynamics by interacting with cofilin and enhancing its function
  • MEMO1 acts as an oncogene and is a potential therapeutic target for cancer treatment
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • MEMO1-RHOA-DIAPH1 signaling coordinates the organization of the lamellipodial actin network, adhesion site formation, and microtubules outgrowth within the cell leading edge to sustain cell motility
  • a component
  • complexes with cofilin, ERBB2 and PLCG1
  • enhances CFL1 depolymerizing and severing activity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with a phospho-Tyr 1227-containing peptide, most probably through the SHC1 adaptor protein
  • ability to complex with ERBB2
  • MEMO1 and PLCG1 interact with ERBB2 autophosphorylation sites and are essential for heregulin-induced chemotaxis
  • interaction between MEMO1 and cofilin (CFL1)
  • bind specifically to an ERBB2-derived phosphorylated peptide encompassing Tyr-1227 (PYD)
  • binds to IRS1, activates the downstream PI3K/AKT signaling pathway, leads to upregulation of SNAI1 and thereby triggers the epithelial-mesenchymal transition (EMT) program
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    increased MEMO1 expression is associated with cancer aggressiveness
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential therapeutic target for cancer treatment
    ANIMAL & CELL MODELS