basic FUNCTION
| may play a role in the signal transduction events in the egg and early embryo |
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FAU, BCLG and MELK, are crucially important in breast cancer |
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responsible for various cellular functions, including early T cell activation, embryonic development, apoptosis, and oncogenesis |
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serine/threonine kinase involved in several cell processes, including the cell cycle, proliferation, apoptosis and mRNA processing |
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is primarily required for proper proliferation, and might play multiple roles in retinal development |
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functions as a modulator of intracellular signaling and affects various cellular and biological processes, including cell cycle, cell proliferation, apoptosis, spliceosome assembly, gene expression, embryonic development, hematopoiesis, and oncogenesis |
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plays a prominent role in cell cycle control, cell proliferation, apoptosis, cell migration, cell renewal, embryogenesis, oncogenesis, and cancer treatment resistance and recurrence |
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is an oncogenic kinase involved in the pathogenesis and recurrence of Hepatocellular carcinoma (HCC) |
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play critical roles in human carcinogenesis through activation of cell proliferation, inhibition of apoptosis and maintenance of stemness |
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MELK is dispensable for the proliferation of cancer cells |
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MELK levels reflect mitotic activity in diverse cell types |
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observed pattern of MELK expression in cancer can be explained by the fact that MELK is up-regulated in mitotic cells |
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serve critical roles in the maintenance of stemness of cancer cells |
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functions likely as a positive regulator of CDKN1A, regulating apoptosis, cell cycle arrest, and metabolism during obesity |
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MELK enhances tumorigenesis, migration, invasion and metastasis of Esophageal squamous cell carcinoma (ESCC) cells via activation of FOXM1 signaling pathway |