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FLASH GENE
Symbol MELK contributors: mct/pgu - updated : 23-08-2012
HGNC name maternal embryonic leucine zipper kinase
HGNC id 16870
Location 9p13.2      Physical location : 36.572.904 - 36.677.678
Synonym name
  • xenopus protein kinase p69EG3 homolog
  • pEg3 kinase
  • protein kinase PK38
  • Synonym symbol(s) KIAA0175, HPK38
    EC.number 2.7.11.1/ 2.7.10.2
    DNA
    TYPE functioning gene
    STRUCTURE 104.82 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    MAPPING cloned Y linked N status provisional
    Physical map
    NPR2 9p21-p12 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) SPAG8 9p13-p12 sperm associated antigen 8 HINT2 9p11.2 histidine triad nucleotide binding protein 2 LOC392307 9 similar to RIKEN cDNA 4930412F15 gene NGX6 9p13.1 nasopharyngeal carcinoma related protein LOC389718 9 LOC389718 LOC392308 9 similar to Olfactory receptor 70 LOC392309 9 similar to Olfactory receptor 13J1 LOC392310 9 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) OR2S2 9p13.3-p13.1 olfactory receptor, family 2, subfamily S, member 2 LOC389719 9 hypothetical gene supported by M24070; NM_004559 LOC392311 9 similar to seven transmembrane helix receptor OR13C7P 9 olfactory receptor, family 13, subfamily C, member 7 pseudogene LOC392313 9 similar to olfactory receptor RECK 9p13-p12 reversion-inducing-cysteine-rich protein with kazal motifs C9orf19 9p12-p13 chromosome 9 open reading frame 19 CCIN 9p13-p12 calicin CLTA 9p13-p12 clathrin, light polypeptide (Lca) GNE 9p13-p12 clathrin, light polypeptide (Lca) LOC392314 9 similar to high mobility group protein homolog HMG4 RNF38 9p13-p12 ring finger protein 38 MRPS21P4 9p13.1 mitochondrial ribosomal protein S21 pseudogene 4 MELK 9p11.2 maternal embryonic leucine zipper kinase PAX5 9p13 paired box gene 5 (B-cell lineage specific activator protein) LOC389720 9 LOC389720 LOC392315 9 similar to 60S ribosomal protein L32 FLJ22611
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 2486 74.5 651 - 2002 11802789
    17 - 2363 - 610 - 2002 11802789
    17 - 2342 - 603 - 2002 11802789
    16 - 2273 - 580 - 2002 11802789
    17 - 2400 - 619 - 2002 11802789
    16 - 2256 - 571 - 2002 11802789
    16 - 2283 - 580 - 2002 11802789
    16 - 2300 - 457 - 2002 11802789
    15 - 2160 - 520 - 2002 11802789
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon  
     stomach    
    Lymphoid/Immunethymus    
     tonsils    
    Reproductivefemale systemplacenta   
     female systemuterus   
     female systemovary   
     male systemtestis   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, interphase
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative transmembrane domain
  • an N-terminal serine/threonine kinase domain, and a mitochondrial targeting signal at the N-terminus of the MC domain
  • a leucine zipper motif
  • catalytic domain
  • HOMOLOGY
    interspecies homolog to Xenopus protein kinase p69EG3
    intraspecies paralog to maternal embryomic leucine zipper kinase
    Homologene
    FAMILY
  • protein kinase superfamily
  • CAMK Ser/Thr protein kinase family
  • SNF1 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • localized in the cytoplasm and the nucleus during interphase and at the cell cortex during anaphase and telophase
  • basic FUNCTION
  • may play a role in the signal transduction events in the egg and early embryo
  • responsible for various cellular functions, including early T cell activation, embryonic development, apoptosis, and oncogenesis
  • serine/threonine kinase involved in several cell processes, including the cell cycle, proliferation, apoptosis and mRNA processing
  • is primarily required for proper proliferation, and might play multiple roles in retinal development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZNF622
  • co-localizes and interacts with anillin an important regulator of cytokinesis
  • cell & other
    REGULATION
    Phosphorylated by MSLN and MAPK (MELK phosphorylation by MSLN and MAPK enhance its activity during M-phase)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS