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FLASH GENE
Symbol MEIS3 contributors: mct - updated : 01-09-2011
HGNC name Meis1, myeloid ecotropic viral integration site 1 homolog 3 (mouse)
HGNC id 29537
Location 19q13.32      Physical location : 47.906.381 - 47.922.785
Synonym name Meis1-related protein 2
Synonym symbol(s) MRG2
DNA
TYPE functioning gene
STRUCTURE 16.40 kb     13 Exon(s)
MAPPING cloned Y linked N status tentative : very preliminary evidence
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1990 - 358 - 2007 17178831
13 - 2174 - 421 - 2007 17178831
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a helix-turn-helix, DNA binding domain, TALE (three AA loop extension between helices) subfamily
  • HOMOLOGY
    interspecies ortholog to murine Meis1 (myeloid ecotropic viral integration site 1)
    homolog to C.elegans T28F12.2B
    intraspecies homolog to PBX1
    Homologene
    FAMILY tale/meis family of homeobox
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • RNA polymerase 2 transcription factor
  • MEIS3 and PBX4 can regulate SHH expression in anterior endoderm, thereby influencing patterning and growth of the foregut
  • potentially having a unique function beyond the traditional roles for TALE (Three-amino-acid-loop-extension) homeodomain factors during embryogenesis
  • potential synergy between MEIS3 and HOXD1 in HOXD1 autoregulation in mesoderm during gastrulation
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding cooperatively with the heterodimer E2A/myogenic transcription factors
    RNA
    small molecule
    protein
  • direct target of Wnt/beta-catenin signaling
  • collaboration between IRF8 deficiency and MEIS1/MEIS3 in the acceleration of chronic myeloid leukemia-like disease
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS