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FLASH GENE
Symbol MEIS2 contributors: mct/npt - updated : 05-02-2019
HGNC name Meis homeobox 2
HGNC id 7001
Corresponding disease
DEL15Q14 chromosome 15q14 deletion
Location 15q14      Physical location : 37.183.232 - 37.393.500
Synonym name
  • Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse)
  • Meis (mouse) homolog 2
  • Meis1-related gene 1
  • TALE homeobox protein Meis2
  • Synonym symbol(s) MRG1, MGC2820, HsT18361
    DNA
    TYPE functioning gene
    STRUCTURE 209.47 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390565 15 LOC390565 LOC390566 15 similar to amyloid beta A4 precursor protein-binding, family A, member 2; neuronal munc18-1-interacting protein 2; X11-like protein; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; neuron-specific X11L protein; ad LOC145990 15q13.2 similar to Heterogeneous nuclear ribonucleoprotein L LOC145989 15q13.2 fascin pseudogene LOC390567 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC145988 15q13.3 similar to golgin-67 isoform c LOC390568 15 LOC390568 LOC390569 15 similar to amyloid beta A4 precursor protein-binding, family A, member 2; neuronal munc18-1-interacting protein 2; X11-like protein; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; neuron-specific X11L protein; ad CX36 15q14 similar to amyloid beta A4 precursor protein-binding, family A, member 2; neuronal munc18-1-interacting protein 2; X11-like protein; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; neuron-specific X11L protein; ad ACTC 15q11-q14 actin, alpha, cardiac muscle LOC390570 15 similar to GLP_457_13116_11626 AQR 15q13.3 likely ortholog of mouse aquarius PRO1914 15q13.3 PRO1914 protein FLJ20582 15q13.3 hypothetical protein FLJ20582 LOC388112 15 similar to Nanog homeobox; homeobox transcription factor Nanog LOC390571 15 similar to Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 snRNP auxiliary factor small subunit) LOC390572 15 similar to Px19-like protein (25 kDa protein of relevant evolutionary and lymphoid interest) (PRELI) (CGI-106) (SBBI12) LOC390573 15 hypothetical gene supported by U60823; BT007436; NM_006305 LOC390574 15 similar to splicing factor (45kD) MGC14798 15q13.3 similar to RIKEN cDNA 5730421E18 gene HH114 15q13.3 hypothetical protein HH114 LOC390575 15 similar to casein kinase 1, alpha 1 MEIS2 15q14 Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse) LOC145846 15q13.3 hypothetical LOC145846 LOC390576 15 similar to ribosomal protein S15 MGC35118 15q13.3 hypothetical protein MGC35118 SPRED1 15q13.3 sprouty-related, EVH1 domain containing 1 FLJ38426 15q13.3 hypothetical protein FLJ38426 RASGRP1 15q15 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 splicing 3721 43.8 401 - Yang (2000)
    also called variant a
    13 splicing 3700 43.1 394 - Yang (2000)
    also called variant b
    12 splicing 3625 51.8 477 - Yang (2000)
    also called variant c
    12 splicing 3604 51.1 470 - Yang (2000)
    also called variant d
    - splicing 3623 32.8 302 - Yang (2000)
    13 splicing 3110 41.5 381 - Yang (2000)
    also called variant f
    12 splicing 2775 42.3 388 - Yang (2000)
    also called variant g
    13 splicing 3175 33.6 306 - Yang (2000)
    also called variant h
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Lymphoid/Immunelymph node    
    nervousbrainbasal nucleiputamen  
    Visualeyeretina  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualamacrine cell
    cell lineage hematopoietic cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text preferentially expressed in distinct cell populations in the developing striatum (Kaoru 2010)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helix-turn-helix, DNA binding domain, TALE (three AA loop extension between helices) subfamily
  • HOMOLOGY
    interspecies ortholog to murine Meis1 (myeloid ecotropic viral integration site 1)
    intraspecies homolog to PBX1
    Homologene
    FAMILY
  • TALE/MEIS homeobox family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as a transcription repressor
  • critical downstream effector within an essential homeoprotein network that serving a rate-limiting regulatory role in MLL leukemogenesis (Wong 2007)
  • midbrain specific marker upregulated concomitantly with the morphological transformation of hindbrain to midbrain (Vennemann 2008)
  • maintain retinal progenitor cells in a rapidly proliferating state and control the expression of some ocular-determination genes and components of the cell cycle machinery (Heine 2008)
  • in combination with PBX3 and FOXP2, may play a pivotal role in the development of striosomal neurons of the striatum and the islands of Calleja (Takahashi 2008)
  • TALE-homeodomain protein necessary and sufficient for tectal development (Agoston 2009)
  • competes with the Groucho co-repressor TLE4 for binding to OTX2 and specifies tectal fate without induction of a secondary midbrain-hindbrain boundary organizer (Agoston 2009)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS cardiovascular , development
    text transcription co-repressor
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding cooperatively with the heterodimer E2A/myogenic transcription factors
    RNA
    small molecule
    protein
  • co-operation between TLX1 and MEIS1, MEIS2 proteins may have a significant role in T-cell leukemogenesis
  • interdependent regulatory loops involving PAX3 and PAX7 in the dorsal mesencephalic vesicle modulate MEIS2 expression
  • is a direct target gene of MEIS2 and is required for MEIS2 to upregulate mitotic genes
  • crucial role for RING1-dependent repression of MEIS2 and likely also MEIS1 for distal specification
  • PBX1 regulates adult neural cell fate determination in a manner beyond that of its heterodimerization partner MEIS2
  • MEIS2 is a novel player in MN1-induced leukemogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL15Q14
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    extensively expressed in ovarian carcinomas and may play a role in ovarian carcinogenesis (Crijns 2007)
    constitutional     --over  
    is a molecular mechanism for high expression of mitotic genes that is frequently observed in cancers of poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • for cleft palate and heart defect
  • combinatorial expression of Meis family proteins might be a candidate mechanism for the differential regulation of eye growth among vertebrate species (Heine 2008)
  • suitable marker for the study of amacrine cell diversity and development in addition to providing evidence for the stepwise specification of the glycinergic and GABAergic neurotransmitter phenotypes during amacrine cell differentiation (Bumsted-O'Brien 2007)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS