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FLASH GENE
Symbol MEIG1 contributors: mct/npt - updated : 11-05-2022
HGNC name meiosis/spermiogenesis associated 1
HGNC id 23429
Location 10p13      Physical location : 15.001.437 - 15.014.850
Synonym name
  • meiosis expressed gene 1 homolog
  • spermatogenesis associated 39
  • Synonym symbol(s) bA2K17.3, SPATA39
    DNA
    TYPE functioning gene
    STRUCTURE 33.82 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 638 - 88 - 2021 33529594
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell Homo sapiens
    ReproductiveSertoli cell Homo sapiens
    Reproductivespermatocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    secondary structure
  • MEIG1 adopts a unique fold that provides a large surface for interacting with other proteins
  • HOMOLOGY
    Homologene
    FAMILY
  • MEIG1 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • chromosome/chromatin-binding protein initially expressed during meiosis but retained in the germ cell nucleus throughout later stages of spermatogenesis (Zhang 2004)
  • involved in folliculogenesis or male fertility
  • MEIG1 regulates spermiogenesis through effects in germ cells alone, and must be active during a discrete period in spermatogenesis after which it is dispensable
  • function of the PACRG family of proteins and MEIG1 in regulating axoneme assembly
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates specifically with meiotic chromosomes (Steiner 1999)
  • associates with the Parkin co-regulated gene (PACRG) protein (critical role for the MEIG1/PARCG partnership in manchette structure and function and the control of spermiogenesis) (Zhang 2009)
  • MEIG1/PACRG forms a complex in the manchette and this complex is necessary to transport cargos, such as SPAG16, to build the sperm flagella
  • MEIG1 is recruited to the manchette, a structure unique to elongating spermatids, by Parkin co-regulated gene (PACRG)
  • PACRG binds to the adaptor protein meiosis expressed gene 1 (MEIG1)
  • MEIG1 is a key protein in determining the manchette localization of certain IFT components, including IFT20 and IFT88, in male germ cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    small molecules that block MEIG1/PACRG interaction are likely ideal targets for the development of male contraconception drugs
    ANIMAL & CELL MODELS