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FLASH GENE

Symbol

MEIG1

contributors: mct/npt - updated : 11-05-2022

HGNC name	meiosis/spermiogenesis associated 1
HGNC id	23429

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10p13      Physical location : 15.001.437 - 15.014.850
Synonym name	meiosis expressed gene 1 homolog
	spermatogenesis associated 39
Synonym symbol(s)	bA2K17.3, SPATA39

DNA

TYPE	functioning gene
STRUCTURE	33.82 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001080836 3 - 638 NP_001074305 - 88 - 2021 33529594

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Reproductive germ cell Homo sapiens Reproductive Sertoli cell Homo sapiens Reproductive spermatocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

secondary structure

MEIG1 adopts a unique fold that provides a large surface for interacting with other proteins

HOMOLOGY

Homologene

FAMILY

MEIG1 family

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	chromosome/chromatin-binding protein initially expressed during meiosis but retained in the germ cell nucleus throughout later stages of spermatogenesis (Zhang 2004)
	involved in folliculogenesis or male fertility
	MEIG1 regulates spermiogenesis through effects in germ cells alone, and must be active during a discrete period in spermatogenesis after which it is dispensable
	function of the PACRG family of proteins and MEIG1 in regulating axoneme assembly

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	associates specifically with meiotic chromosomes (Steiner 1999)
	associates with the Parkin co-regulated gene (PACRG) protein (critical role for the MEIG1/PARCG partnership in manchette structure and function and the control of spermiogenesis) (Zhang 2009)
	MEIG1/PACRG forms a complex in the manchette and this complex is necessary to transport cargos, such as SPAG16, to build the sperm flagella
	MEIG1 is recruited to the manchette, a structure unique to elongating spermatids, by Parkin co-regulated gene (PACRG)
	PACRG binds to the adaptor protein meiosis expressed gene 1 (MEIG1)
	MEIG1 is a key protein in determining the manchette localization of certain IFT components, including IFT20 and IFT88, in male germ cells

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed reproduction contraception   small molecules that block MEIG1/PACRG interaction are likely ideal targets for the development of male contraconception drugs

ANIMAL & CELL MODELS