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FLASH GENE
Symbol MEGF8 contributors: mct - updated : 05-12-2012
HGNC name multiple EGF-like-domains 8
HGNC id 3233
Location 19q13.2      Physical location : 42.829.760 - 42.882.920
Synonym name
  • multiple epidermal growth factor-like motif 8
  • EGF-like-domain, multiple 4
  • chromosome 19 open reading frame 49
  • HBV pre s2 binding protein 1
  • EGF-like domain-containing protein 4
  • multiple epidermal growth factor-like domains 8
  • Synonym symbol(s) EGFL4, C19orf49, SBP1, FLJ22365, KIAA0817, MGC138147, MGC120684
    DNA
    TYPE functioning gene
    STRUCTURE 53.16 kb     41 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    41 - 10966 - 2778 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • membrane anchored protein with a laminin type EGF-like
  • five EGF-like motifs
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • essential regulator of left-right patterning (
  • possible involvement in astrocytic engulfment
  • function for MEGF8 in intracellular trafficking could account for both the presence of the predicted transmembrane domain and the phenotypic similarity in the consequences of MEGF8 and RAB23 mutations
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS