basic FUNCTION
| mediating calcium-dependent transcription of the interleukin-2 gene in T lymphocytes |
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activating transcription via the MEF2 element present in the regulatory regions of many muscle-specific genes |
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may be involved in muscle-specific and/or growth factor-related transcription |
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DNA binding proteins activating transcription of genes involved in control of muscle cell differentiation, and signaling pathways that mediate response to mitogenic signals and survival of neurons and T-lymphocytes |
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implicated in neuronal activity-dependent cell survival, and may be regulate excitatory synapse number and postsynaptic differentiation of dendrites |
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regulate neuronal development by controlling synapse formation and supporting the survival of newly formed neurons |
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nuclear transcription factor known to promote neuronal survival |
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transcription factor required for neuronal survival, that continuously shuttle to the cytoplasm, interact with the chaperone Hsc70, and undergo degradation |
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possible dual roles of MEF2A and MEF2D in macrophages, as activators or as repressors of gene transcription |
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neuronal survival factor MEF2D is decreased in Parkinson disease, and this decrease is specifically associated with SNCA accumulation and aggregation |
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key role of MEF2C isoform in the brain, suggesting that MEF2A and MEF2D have only subtle roles in regulating hippocampal synaptic function ( |
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essential and redundant roles of MEF2A, MEF2C, and MEF2D in satellite cell differentiation |
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MEF2D is essential for photoreceptor and bipolar cell gene expression, either independently or cooperatively with CRX |
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in the retina MEF2D binds to retina-specific enhancers and controls photoreceptor cell development |
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is a key transcriptional mediator of pathological remodeling in the adult heart downstream of various stress-promoting insults |
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novel role for MEF2C/MEF2D in coordinating the transcriptional network that promotes early B-cell development |