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FLASH GENE
Symbol MED7 contributors: mct - updated : 30-08-2014
HGNC name mediator complex subunit 7
HGNC id 2378
Location 5q33.3      Physical location : 156.565.452 - 156.569.921
Synonym name
  • cofactor required for Sp1 transcriptional activation, subunit 9 (33kD)
  • CRSP complex subunit 9
  • transcriptional coactivator CRSP33
  • activator-recruited cofactor 34 kDa component
    • Synonym symbol(s) CRSP33, CRSP9, MGC12284
    DNA
    TYPE functioning gene
    STRUCTURE 4.47 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1400 - 233 - 2005 15710619
    2 - 1116 - 233 - 2005 15710619
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Endocrineadrenal gland   highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to S.cerevisiae mediator subunit med7
    Homologene
    FAMILY
    CATEGORY transcription factor , receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • global coactivator for the nuclear receptor family
  • coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription coactivator
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • component of the CRSP coactivation complex,mediating,import,activator-dependent recruitment of RNA POLII
  • middle module of the Mediator core contains a submodule of unique structure and function that comprises the N-terminal part of subunit MED7 (MED7N) and the highly conserved subunit MED31
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RNA polymerase POLII via its carboxy terminal domain
  • activating SP1
  • MED1 directly binds to the MED7 subunit and ERK phosphorylation of MED1 enhances this interaction
  • MED7N/MED31 has a predominantly positive function on the expression of a specific subset of genes, including genes involved in methionine metabolism and iron transport
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS