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FLASH GENE
Symbol MED4 contributors: mlc - updated : 19-12-2007
HGNC name mediator complex subunit 4
HGNC id 17903
Location 13q14.12      Physical location : 48.650.091 - 48.669.240
Synonym name
  • HSPC126 protein
  • p36 TRAP/SMCC/PC2 subunit
  • vitamin D receptor interacting protein
  • mediator of RNA polymerase II transcription, subunit 4 homolog
  • Synonym symbol(s) HSPC126, DRIP36, VDRIP, FLJ10956, RP11-90M2.2, TRAP36
    DNA
    TYPE functioning gene
    STRUCTURE 19.00 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2022 - 270 - Conaway (2005)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Nervousbrain    
    Reproductivefemale systemplacenta   
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text umbilical cord blood, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer complex
    HOMOLOGY
    interspecies homolog to murine Vdrip
    homolog to rattus LOC306030
    Homologene
    FAMILY
    CATEGORY transcription factor , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • plays a role in transcriptional coactivation
  • coactivator required for transcriptional activation of RNA polymerase II transcribed genes by DNA binding transcription factors
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component subunit of the large multiprotein complexes ARC/DRIP and PC2
    INTERACTION
    DNA
    RNA
    small molecule
    protein binds nuclear receptors in a ligand-dependent manner
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS