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FLASH GENE
Symbol MED31 contributors: mct - updated : 25-08-2014
HGNC name mediator complex subunit 31
HGNC id 24260
Location 17p13.2      Physical location : 6.546.633 - 6.554.954
Synonym name
  • mediator of RNA polymerase II transcription, subunit 31 homolog (yeast)
  • mediator complex subunit SOH1
  • Synonym symbol(s) CGI-125, FLJ27436, FLJ36714, Soh1
    DNA
    TYPE functioning gene
    STRUCTURE 8.49 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1656 - 131 - 2009 19057509
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , complex
    HOMOLOGY
    interspecies ortholog to drosophila Trap18
    Homologene
    FAMILY mediator SOH1 subunit family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    text mediator complex
    basic FUNCTION
  • can either repress or activate transcription
  • being essential for basal and regulated expression of nearly all RNA polymerase II-dependent genes
  • may act as a bridge, conveying regulatory information from enhancers and other control elements to the promoter
  • can also act independently of the RNA polymerase II CTD
  • likely functions to promote the transcription of genes required for embryonic growth and cell proliferation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the SMCC mediator complex composed of MED21, CDK8/SRB10, CCNC/SRB11, MED6, MED14/RGR1, MED31, NUT2, MED1/TRAP220, and TRAP100
  • middle module of the Mediator core contains a submodule of unique structure and function that comprises the N-terminal part of subunit MED7 (MED7N) and the highly conserved subunit MED31
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MED7N/MED31 has a predominantly positive function on the expression of a specific subset of genes, including genes involved in methionine metabolism and iron transport
  • binding between ELMO1 and the Mediator complex subunit MED31 (ELMO1 is a novel regulator of MED31, revealing a previously unrecognized link between cytoplasmic signaling proteins and the mediator complex)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Med31 mutants have normal limb bud patterning but defective or delayed chondrogenesis due to a lack of Sox9 and Col2a1 expression