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FLASH GENE
Symbol MED28 contributors: mct - updated : 07-10-2013
HGNC name mediator of RNA polymerase II transcription, subunit 28 homolog (yeast)
HGNC id 24628
Location 4p15.31      Physical location : 17.616.272 - 17.626.160
Genatlas name magicin
Synonym name
  • endothelial-derived gene 1
  • merlin and Grb2 interacting cytoskeletal protein
  • tumor angiogenesis marker EG-1
  • Synonym symbol(s) EG1, magicin, FKSG20
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 9.89 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1363 - 178 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Lymphoid/Immunetonsils   highly
    Reproductivemale systemtestis   
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    binding motifs for the adaptor protein GRB2
    HOMOLOGY
    interspecies ortholog to murine Med28
    Homologene
    FAMILY mediator complex subunit 28 family
    CATEGORY transcription factor , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text associates with the actin cytoskeleton
    basic FUNCTION
  • may be having a role in tumor angiogenesis
  • involved in transcription regulation, DNA-dependent
  • functioning as a negative regulator of smooth muscle cell differentiation in concert with other Mediator subunits including MED6, MED8, and MED18 within the Mediator head module
  • function as a scaffolding protein by maintaining the stability of a submodule within the head module and the components of this submodule act together in a gene regulatory program to suppress smooth muscle cell differentiation
  • actin cytoskeleton-associated protein, involved in transcriptional regulation, therefore and may serve as a multi-faceted adaptor/scaffold to relay cellular signaling to the cytoskeleton and from the cytoskeleton to the nucleus
  • implicated in transcriptional control, signal regulation, and cell proliferation and has also been associated with tumor progression
  • regulates cellular migration in a MAP2K1-dependent manner in breast cancer cells, reinforcing the important cellular roles of MED28
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • merlin-specific binding partner and the two proteins interact as well as colocalize beneath the plasma membrane
  • interaction between GRB2 and magicin
  • Fyn tyrosine kinase as a specific binding partner(phosphorylates magicin)
  • cell & other
    REGULATION
    induced by endothelial cells when exposed to tumor conditional media
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast, colon, prostate cancer
    tumoral     --over  
    in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • novel and strong independent prognostic indicator of survival for breast cancer
  • Therapy target
    ANIMAL & CELL MODELS