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FLASH GENE
Symbol MED26 contributors: mct - updated : 04-04-2012
HGNC name mediator complex subunit 2
HGNC id 2376
Location 19p13.11      Physical location : 16.685.717 - 16.739.015
Synonym name
  • cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa
  • CRSP complex subunit 7
  • transcriptional coactivator CRSP70
  • Synonym symbol(s) CRSP70, CRSP7
    DNA
    TYPE functioning gene
    STRUCTURE 53.30 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3184 - 600 - 2002 12050112
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
     salivary gland   highly
    Hearing/Equilibriumear   highly
    Reproductivefemale systemovary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain (NTD) contributes to MED26-dependent gene regulation, and may function as a molecular switch that contributes to the transition of Pol II into productive elongation
  • a BC (SOCS) box motif of homolog elongin A (TCEB3)
  • HOMOLOGY
    intraspecies paralog to elongin factor TFIIS
    Homologene
    FAMILY
    CATEGORY receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • global coactivator for the nuclear receptor family
  • coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors
  • MED26-containing Mediator appears to play a key role in transcriptional activation
  • might contribute to transcriptional regulation at least in part by helping to recruit them to the genes they regulate
  • can function as a molecular switch that interacts first with TBP in the Pol II initiation complex
  • controls expression of genes regulated during elongation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription coactivator
    PATHWAY
    metabolism
    signaling hormonal
    a component component of the CRSP coactivation complex, mediating, import, activator-dependent recruitment of RNA PolII
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RNA polymerase POLII via its carboxy terminal domain
  • activating SP1
  • MED19 and MED26 subunits in Mediator are direct physical and synergistic functional targets of REST
  • can recruit EAF1 or EAF1-associated complexes to immobilized promoters via direct interaction of the MED26 NTD with EAF1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS