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FLASH GENE
Symbol MED24 contributors: mct - updated : 18-10-2016
HGNC name mediator complex subunit 24
HGNC id 22963
Location 17q21.1      Physical location : 38.175.350 - 38.210.889
Synonym name
  • thyroid hormone receptor associated protein 4
  • activator-recruited cofactor 100 kDa component
  • cofactor required for Sp1 transcriptional activation, subunit 4, 100kDa
  • mediator of RNA polymerase II transcription, subunit 24 homolog
  • Synonym symbol(s) DRIP100, TRAP100, KIAA0130, THRAP4, ARC100, CRSP100, CRSP4, MGC8748
    DNA
    TYPE functioning gene
    STRUCTURE 34.00 kb     25 Exon(s)
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3735 - 989 - Olsen (2006)
    - - 3718 - 976 - Olsen (2006)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Lymphoid/Immunespleen   lowly
    Nervousbrain   highly
    Reproductivefemale systembreastmammary gland  
     male systemtestis  highly
    Respiratorylung   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a P-loop predicted to be an ATP/GTP-binding site
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in nuclear hormone receptor-mediated transactivation
  • coactivator required for transcriptional activation of RNA polymerase II transcribed genes by DNA binding transcription factors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulates the proper splicing of transcripts encoding for pluripotency regulators such as POU5F1, PRDM14, E4F1 and MED24
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS