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FLASH GENE

Symbol

MED23

contributors: mct - updated : 25-08-2011

HGNC name	mediator complex subunit 23
HGNC id	2372

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MRT18 Mental retardation, autosomal recessive 18
Location	6q23.2      Physical location : 131.895.107 - 131.949.363
Synonym name	Vitamin D3 receptor interacting protein
	cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa
	cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa
	transcriptional co-activator CRSP130
Synonym symbol(s)	SUR2, CRSP130, CRSP133, DRIP130, CRSP3, DKFZp434H0117

DNA

TYPE	functioning gene
STRUCTURE	54.26 kb     31 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004830 29 - 5227 - 1368 - 2007 16964286 NM_015979 31 - 4616 - 1365 - 2007 16964286

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous nerve       highly Reproductive male system prostate       Respiratory respiratory tract larynx     highly   respiratory tract trachea     highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to murine Crsp3

Homologene

FAMILY

CATEGORY

transcription factor , receptor nuclear

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm

basic FUNCTION	required for Sp1 mediated transcriptional activation with TAF(II)s
	global coactivator for the nuclear receptor family
	key regulator in KISS1 transactivation in normal tissue, and the loss of MED23 expression, provokes increased tumor metastasis
	plays a key role in sensing developmental and environmental signals to deliver adequate outputs to the transcription machinery
	mediates the immediate early gene (IEG) response to serum mitogens
	serves as a critical link transducing insulin signaling to the transcriptional cascade during adipocyte differentiation
	is required to link enhancer-bound TCF4 with the basal transcription machinery ()
	key role of the MED23 subunit in organizing protein interactions within the transactivation complex ()

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

text	transcription coactivator

PATHWAY

metabolism

signaling

hormonal

a component	130 kDa subunit of the CRSP complex
	component of the CRSP coactivation complex, mediating, import, activator-dependent recruitment of RNA PolII
	also component of the DRIP complex

INTERACTION

DNA

binding

RNA

small molecule

protein	RNA polymerase POLII via its carboxy terminal domain
	activating SP1
	vitamin D receptor
	MED23 subunit of the Mediator Complex and its interacting transcription factor ELK1 are critical regulators of adipogenesis
	interaction with MED23 stimulates initiation by promoter bound Pol II in addition to Pol II and GTF recruitment (

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MRT18

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   results in reduced KISS1 promoter activation in highly malignant melanoma cells

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS