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FLASH GENE
Symbol MED19 contributors: mct - updated : 11-04-2012
HGNC name mediator of RNA polymerase II transcription, subunit 19 homolog (yeast)
HGNC id 29600
Location 11q12.1      Physical location : 57.471.188 - 57.479.673
Synonym name
  • lung cancer metastasis-related protein 1
  • mediator complex subunit 19
  • Synonym symbol(s) LCMR1
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 8.49 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1605 - 194 - Sato (2004)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunetonsils   highly
    Nervousbrainhindbrainmedulla oblongata  
    Urinarykidneytubuleconvoluted tubuleproximal tubule 
    Visualeyelens   
     eyeanterior segmentiris  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Connectivebone  highly
    Connectivebone  highly
    Epithelialsensoryolfactory  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • multiprotein coactivator required for activation of RNA polymerase II transcription by DNA binding transactivators
  • novel proliferation regulator that promotes growth of lung cancer cells
  • plays a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas
  • serves as a novel proliferation regulator that promotes growth of prostate cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MED19 and MED26 subunits in Mediator are direct physical and synergistic functional targets of REST
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    may serve as a new molecular target for lung cancer therapy
    ANIMAL & CELL MODELS