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FLASH GENE

Symbol

MED16

contributors: mlc - updated : 19-12-2007

HGNC name	mediator complex subunit 16
HGNC id	17556

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.3      Physical location : 867.961 - 893.218
Synonym name	vitamin D receptor -interacting protein ,92-KD
	thyroid hormone receptor associated protein 5
	thyroid hormone receptor-associated protein, 95-kD subunit
Synonym symbol(s)	DRIP92, TRAP95, THRAP5

DNA

TYPE	functioning gene
STRUCTURE	25.00 kb     16 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 16 - 2952 - 877 - Sato (2004)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Endocrine parathyroid       highly Reproductive female system ovary     highly Visual eye lens         eye anterior segment iris       eye uvea choroid

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining retinal pigment epithelium (RPE)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a short leucine zipper near the N terminus

HOMOLOGY

Homologene

FAMILY

CATEGORY

receptor nuclear

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS