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FLASH GENE
Symbol MED15 contributors: npt/ - updated : 28-08-2007
HGNC name mediator complex subunit 15
HGNC id 14248
Location 22q11.21      Physical location : 20.861.885 - 20.941.918
Synonym name
  • TPA inducible gene 1
  • trinucleotide repeat containing 7
  • activator-recruited cofactor, 105-kD
  • PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein
  • PC2-glutamine-rich-associated protein
  • positive cofactor 2 glutamine/Q-rich-associated protein
    • Synonym symbol(s) TIG1, ARC105, TNRC7, CAG7A, PCAP, CTG7A, PCQAP, PC2, DKFZp686A2214, FLJ42935, DKFZp762B1216, FLJ42282
    DNA
    TYPE functioning gene
    STRUCTURE 80.03 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 splicing 3384 86 788 - -
    encoding for the longer product
    17 splicing 3264 82 748 - -
    lacking exon 9
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestivemouthtongue  highly
    Endocrinepancreas   highly
    Lymphoid/Immunethymus   highly
     tonsils   highly
    Nervousbrain   moderately
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text heart, thymus, tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • glutamine-rich regions and a proline rich extension
  • a Kix domain
  • a nuclear localisation signal
    • HOMOLOGY
    interspecies homolog to rattus Pcqap (93.19 pc)
    homolog to murine Pcqap (91.55 pc)
    Homologene
    FAMILY
  • mediator complex subunit 15 family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in mediating gene activation by several classes of transcriptional regulators
  • may function as a transcriptional coactivator in RNA polymerase II transcription
  • with PLAGL1, and SPI1 cooperate to enhance NCF2 promoter-reporter activity (Wezensky 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    TGF Beta/Nodal signaling
    a component
  • subunit of the large multiprotein complexes PC2 and ARC/DRIP
  • component of the ARC/Mediator complex (Wezensky 2010)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to nuclear receptor transactivation domains
  • interacting with TAZ
  • interaction between PLAGL2 and MED15 (interacts with the C-terminal domain of PLAGL2 and important modulator of PLAGL2 transactivation)(Wezensky 2010)
    • cell & other
    REGULATION
    induced by TPA
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in Di George syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS