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FLASH GENE
Symbol ME3 contributors: mct - updated : 25-06-2013
HGNC name malic enzyme 3, NADP(+)-dependent, mitochondrial
HGNC id 6985
Location 11q14.2      Physical location : 86.152.151 - 86.383.678
Synonym name
  • NADP-ME
  • pyruvic-malic carboxylase
  • Synonym symbol(s) FLJ34862, m-NAD(P)-ME
    EC.number 1.1.1.40
    DNA
    TYPE functioning gene
    STRUCTURE 231.53 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    PCF11 11q13 pre-mRNA cleavage complex II protein Pcf11 DKFZp547G183 11q13.5 hypothetical protein DKFZp547G183 FLJ37874 11q13.5-q14.1 hypothetical protein FLJ37874 MDS025 11q14.1 hypothetical protein MDS025 HCP28 11q14.1 cytochrome c, somatic pseudogene FLJ37266 11q14.1 hypothetical protein FLJ37266 DLG2 11q21 discs, large homolog 2, chapsyn-110 (Drosophila) LOC390229 11 similar to HNRPC protein LOC143548 11q14.1 similar to REST corepressor HT007 11q14.1 uncharacterized hypothalamus protein HT007 DKFZp586C1924 11q14.1 hypothetical protein DKFZp586C1924 ZF 11q14 HCF-binding transcription factor Zhangfei FLJ38159 11q14.1 hypothetical protein FLJ38159 SYTL2 11q14 synaptotagmin-like 2 MGC34732 11q14.1 hypothetical protein MGC34732 PICALM 11q14 phosphatidylinositol binding clathrin assembly protein LOC283226 11q14.1 similar to Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit (CAAX farnesyltransferase alpha subunit) (Ras proteins prenyltransferase alpha) (FTase-alpha) (Type I protein geranyl-geranyltransferase alpha sub EED 11q14.2-q22.3 embryonic ectoderm development HSPC138 11q14.1 hypothetical protein HSPC138 LOC387796 11 LOC387796 FLJ23514 11q14.1 hypothetical protein FLJ23514 ME3 11q21 malic enzyme 3, NADP(+)-dependent, mitochondrial LOC387797 11 LOC387797 SPUVE 11q14.1 protease, serine, 23 OR7E13P 11q13-q14.3 olfactory receptor, family 7, subfamily E, member 13 pseudogene OR7E2P 11q13-q14 olfactory receptor, family 7, subfamily E, member 2 pseudogene FZD4 11q14.2 frizzled homolog 4 (Drosophila) FLJ22104 11q14.1 hypothetical protein FLJ22104 RAB38 11q14 RAB38, member RAS oncogene family CTSC 11q21 cathepsin C LOC390230 11 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) GRM5 11q13-q13.4 glutamate receptor, metabotropic 5 TYR 11q14.3 tyrosinase (oculocutaneous albinism IA) NOX4 11q14.2-q21 NADPH oxidase 4 PSMAL/GC
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2090 - 604 - 1994 7818469
    14 - 2242 - 604 - 1994 7818469
    15 - 2329 - 604 - 1994 7818469
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    Text predominantly, in tissues with a low division rate
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY secretory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • catalyzing the decarboxylation of malate to pyruvate
  • catalyzing the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor
  • behaves cooperatively and allosterically and exhibits a quaternary structure in dimer-tetramer equilibrium
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • exists as a mixture of dimers and tetramers
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS