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FLASH GENE
Symbol MDS2 contributors: - updated : 04-01-2006
HGNC name myelodysplastic syndrome 2 translocation associated
HGNC id 29633
Location 1p36.1      Physical location : 23.953.823 - 23.967.056
Synonym name myelodysplastic syndrome gene 2
Synonym symbol(s) RP11-223J15.1
DNA
TYPE functioning gene
STRUCTURE 13.00 kb     7 Exon(s)
regulatory sequence Promoter (TATA box)
text structure one TATA box
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 1020 - 82 - Odero
exon 1,4,6,7
- splicing - - 82 brain specific Odero
exon 1,2,3,4,6,7
- splicing - - 140 pancreas,skeletal muscle and leukocytes Odero
exon 1,4,5,6,7
- splicing - - 82 spleen,thymus,kidney and low in lung pancreas Odero
exon 1,3,4,6,7
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
 thymus   highly
Digestiveintestinesmall intestine  lowly
 liver   lowly
Endocrinepancreas   highly
Reproductivefemale systemovary  lowly
 male systemprostate  lowly
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
with ETV6 in t(1;12)(p36;p13) in myelodysplastic syndrome
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS