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FLASH GENE

Symbol

MDFIC

contributors: mct - updated : 26-08-2019

HGNC name	MyoD family inhibitor domain containing
HGNC id	28870

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7q31.1      Physical location : 114.562.208 - 114.659.970
Genatlas name	human I-mfa domain C-containing protein
Synonym symbol(s)	HIC, HIC1

DNA

TYPE	functioning gene
STRUCTURE	97.80 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	two isoforms,p32 localized in the cytoplasm,p40 localized in the nucleolus

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_199072 5 splicing 5312 NP_951038 40 355 nucleolar 2009 19582149 HIC p40 NM_001166345 5 splicing 5312 NP_001159817 32 246 cytoplasmic 2009 19582149 HIC p32 NM_001166346 3 - 891 NP_001159818 - 152 - 2009 19582149

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	cysteine-rich C terminus
	C-terminal I-mfa domains, acting as a dominant negative inhibitor

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleolus

basic FUNCTION	regulating gene expression
	modulating expression from both cellular and viral promoters via its C-terminal cysteine-rich domain, which is similar to the inhibitor of MyoD family a (I-mfa) protein
	functions as a transcriptional regulator
	putative role in the modulation of immune and inflammatory responses and/or hematological malignancies
	differentially regulates transcription from viral promoters
	expression of MDFIC and its involvement in the various pathways is required only under specific cellular conditions
	MDFI and MDFIC interact with SERTA domain proteins SERTAD1, SERTAD2, SERTAD3, SERTAD4) and negatively regulate their transcriptional activity

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	MDFI and MDFIC specifically interact with SERTAD1 through their C-terminal I-mfa domains
	MDFIC is a binding partner for NR3C1, and NR3C1 directly represses the MDFIC gene, revealing a negative feedback loop by which glucocorticoids limit MDFIC activity

cell & other

REGULATION

Other

inhibition of luciferase expression from HIV1 and activation of expression of luciferase in T cells

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS