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FLASH GENE
Symbol MCTS1 contributors: mct - updated : 22-01-2011
HGNC name malignant T cell amplified sequence 1
HGNC id 23357
Location Xq24      Physical location : 119.737.743 - 119.755.011
Synonym name
  • gene with multiple copies in T cell malignancy 1
  • MCTS1 protein
  • Synonym symbol(s) MCT-1, MCT1, FLJ39637
    DNA
    TYPE functioning gene
    STRUCTURE 17.27 kb     6 Exon(s)
    regulatory sequence Promoter
    Binding site   enhancer
    text structure contains a cis-acting element and two Sp1 sites
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 9805 - 181 - 2003 12938157
    6 - 9617 - 182 - 2003 12938157
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Lymphoid/Immunethymus    
    Urinarybladder    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines highly in B-cell lymphoma, amplified in T-cell lymphoma and NHL
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PUA, RNA binding domain
  • HOMOLOGY
    interspecies ortholog to murine Mcts1
    ortholog to rattus mcts1
    intraspecies homolog to homolog to cyclin Ha protein-protein binding domain
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • potential role in regulation of cell cycle
  • protects against apoptosis, maybe by enhancing AKT kinase activation
  • potential role in promoting lymphoid tumor development
  • accelerates TP53 degradation by means of the ubiquitin-dependent proteolysis
  • loss of TP53, with its overexpression synergistically promote chromosome instability and tumorigenicity
  • implicated in the interaction with the cap complex of the mRNA, through an RNA binding domain, named PUA
  • LGTN and MCTS1/DENR promote release of tRNA and mRNA from recycled 40S subunits
  • roles for Ligatin and the related interacting proteins MCTS1 and DENR in ribosome recycling and initiation, two linked stages of translation
  • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    suggested to be involved in human breast cancer
    tumoral     --over  
    in lymphomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target targeted suppression of this domain attenuates the malignant phenotype and is a potential target for therapeutic intervention in lymphomas
    SystemTypeDisorderPubmed
    cancerhemopathy 
    ANIMAL & CELL MODELS