Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MCRS1 contributors: mct - updated : 28-02-2016
HGNC name microspherule protein 1
HGNC id 6960
Location 12q13.12      Physical location : 49.952.085 - 49.961.911
Synonym name
  • cell cycle-regulated factor (78 kDa)
  • INO80 complex subunit J
  • INO80 complex subunit Q
  • Synonym symbol(s) ICP22B, MSP58, P78 , TOJ3
    DNA
    TYPE functioning gene
    STRUCTURE 9.85 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked   status provisional
    Map pter - D12S333 - PTHLH - D12S345 - D12S331 - D12S85 - VDR -PFKM - LALBA - ARF3 - D12S339 - MCRS1 - D12S347 - D12S1635 - POU6F1 - D12S368 - ITGB7 - D12S325 - cen
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 1961 - 462 - 2007 17109818
    12 - 1785 58 475 - 2007 17109818
    13 - 1702 - 271 - 2007 17109818
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivesalivary gland   highly
    Endocrinepancreas    
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    Text associated with the proliferation-related nucleolar protein (NOL1) which is detectable early in the G1 phase of the cell cycle and peaks early in the S phase
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal region with serine-rich clusters, interacting with the phosphorylation domain of FMR1
  • bipartite nuclear localization signal
  • a region containing the forkhead-associated domain involved in association with NDE1 and Su48, as well as in centrosomal localization
  • a C terminal coiled-coil domain
  • HOMOLOGY
    interspecies homolog to murine Mcrs1
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • present on polyribosomes prepared from synaptoneurosomes
  • co-localized with CCD85B to the nucleus
  • UBR5 and MCRS1 co-localize in the nucleus
  • basic FUNCTION
  • RNA-binding protein, potentially affecting the size and shape of the nucleolus
  • forkhead-associated domain containing protein implicated in malignant transformation as well as in regulation of gene transcription and translation
  • playing an essential role for cell viability
  • might play an important role in the carcinogenesis of colorectal cancer via regulation of the CCND1-CDK4-CDKN1A pathway
  • activates the DNA damage response and TP53/CDKN1A signaling pathways
  • role in modulating cellular senescence, suggesting that MCRS1 has both oncogenic and tumor-suppressive properties
  • plays an oncogenic role in the proliferation of neuroblastoma cells
  • plays a role in numerous cellular processes including transcriptional regulation and cell proliferation
  • plays an important role in a variety of cellular processes including transcriptional regulation, cell proliferation and oncogenic transformation
  • novel function in cellular senescence
  • inhibitory effect of MCRS1 occurred through inhibition of SCYL1 binding to DNA
  • MCRS1 as a dynein-interacting protein critical for centriolar satellite formation and ciliogenesis
  • nucleolar protein involved in rDNA transcription and cell proliferation
  • role for MCRS1 and RINT1 in cancer development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • colocalizing and associating with NOL1
  • modulating DAXX-dependent transcriptional repression
  • target of v-Jun transcription factor
  • cellular partner for FMR1 escorting FMR1-containing mRNP from the nucleus and nucleolus to the somato-dendritic compartment where it might participate in neuronal translation regulation
  • bound to the ATPase/helicase region of CHD4 and the coiled-coil region of TRIM27
  • interacting with FMR1 (predominantly present in the nucleus where it interacts with the nuclear isoform of FMR1)
  • interacting partner of NDRG2, through its forkhead associated domain (the modulation of NDRG2 level influences the cell cycle process together with MCRS1)
  • interacting with CCDC85B
  • UBR5 is a novel MCRS1-interacting protein, that negatively regulates MCRS1 protein stability
  • SCYL1 is a novel MCRS1-interacting protein
  • negative regulator of TERT expression and telomerase activity
  • unlike NDE1, MCRS1 played a positive role for the initiation of ciliogenesis, possibly through its interaction with TTBK2
  • MCRS1 directly interacts with RINT1
  • cell & other interacting with HSV1 viral transcription factor ICP22
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in neuroblastoma tumor samples and cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    could be a novel target for the treatment of neuroblastoma
    ANIMAL & CELL MODELS