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FLASH GENE
Symbol MCM6 contributors: npt/mct - updated : 07-04-2010
HGNC name minichromosome maintenance complex component 6
HGNC id 6949
Location 2q21.3      Physical location : 136.597.203 - 136.634.011
Synonym name
  • MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
  • early S-phase-like-6
  • DNA replication licensing factor MCM6
  • MIS5 homolog (S.pombe)
    • Synonym symbol(s) Mis5, MCG40308, P105MCM
    DNA
    TYPE functioning gene
    STRUCTURE 36.82 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    regionally located located cystream of the lactase gene (LCT)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3769 - 821 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, G1
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal phosphorylation site (phosphorylation play functionally redundant but essential roles in initiation of DNA replication)
  • CDT1 binding domain (CBD) (Wei 2010)
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae replication Mcm6 (minichromosome maintenance mutant)
    intraspecies homolog to cell division cycle
    Homologene
    FAMILY
  • MCM family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • participating in the cell cycle control of genome duplication
  • playing an essential role for the initiation of eukaryotic genome replication
  • during S phase MCM6 functions as part of the replicative helicase but within the pre-replication, MCM6 is inactive
    • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA DNA binding
    RNA
    small molecule
    protein
  • MCM8
  • specific MRC1-binding protein (binding of MRC1, a checkpoint mediator, to MCM6, a replication helicase, is essential for the replication checkpoint against methyl methanesulfonate-induced stress)(Komata 2009)
  • interaction between CDT1 and MCM6 appears to be essential for efficient loading of MCM6 onto template DNA (You 2008)
  • interacting with ARHGEF5 and TIPIN, both of which are involved in regulation of DNA replication fork progression (Numata 2010)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in classic Hodgkin lymphoma (Karimi 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS