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FLASH GENE
Symbol MCM5 contributors: mct - updated : 06-11-2010
HGNC name minichromosome maintenance complex component 5
HGNC id 6948
Location 22q12.3      Physical location : 35.796.115 - 35.820.494
Synonym name
  • MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
  • DNA replication licensing factor
  • CDC46 homolog
  • Synonym symbol(s) CDC46, MCMD5, EVI91, P1-CDC46, MGC5315
    DNA
    TYPE functioning gene
    STRUCTURE 24.38 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC388895 22 LOC388895 LOC388896 22 hypothetical gene supported by BX537993 COX7BP1 22q13 cytochrome c oxidase subunit VIIb pseudogene 1 HMG2L1 22q13.1 high-mobility group protein 2-like 1 LOC388897 22 LOC388897 TOM1 22q13.1 target of myb1 (chicken) HMOX1 22q13.1 heme oxygenase (decycling) 1 MCM5 22q13.1 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) RASD2 22q13.1 RASD family, member 2 MB 22q13.1 myoglobin LOC284912 22q13.1 hypothetical gene supported by BC001801 APOL6 22q13.1 apolipoprotein L, 6 MRPS16P3 22q12-q13.1 apolipoprotein L, 6 APOL5 22q13.1 apolipoprotein L, 5 RBM9 22q13.1 RNA binding motif protein 9 RPL41P3 22q13.1 ribosomal protein L41, pseudogene 3 NDUFA9P1 22q12.3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, pseudogene 1 APOL3 22q13.1 apolipoprotein L, 3 APOL4 22q13.1 apolipoprotein L, 4 APOL2 22q13.1 apolipoprotein L, 2 APOL1 22q13.1 apolipoprotein L, 1 MYH9 22q13.1 myosin, heavy polypeptide 9, non-muscle LOC388898 22 LOC388898 TXN2 22q13.1 thioredoxin 2 FLJ23322 22q13.1 hypothetical protein FLJ23322 EIF3S7 22q13.1 eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2568 - 734 - 2001 11248027
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a central ATPase/helicase region
  • a MCM domain
  • domain responsible for interaction with cyclin E is distinct from any previously described for MCM5 function and is highly conserved in MCM5 proteins from yeast to mammals
  • a domain in MCM5 that mediates the interaction between STAT1 and MCM5
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae replication Mcm5 (minichromosome maintenance mutant)
    intraspecies homolog to cell division cycle 46 (CDC46)
    Homologene
    FAMILY
  • MCM family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in an early step of DNA replication
  • participating in the cell cycle control of genome duplication
  • upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation
  • essential for transcription activation of STAT1 target genes, and in addition to their roles in DNA replication, the MCM proteins are also necessary for transcription activation
  • during S phase MCM5 functions as part of the replicative helicase but within the pre-replication, MCM5 is inactive
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting directly with STAT1 and resulting in the recruitment of a MCM5/MCM3 complex in the process of IFNG-induced gene activation
  • strong interaction between STAT1 and MCM5
  • interacting with ARHGEF5 and TIPIN, both of which are involved in regulation of DNA replication fork progression
  • interaction with CCNE1 (cyclin E is shown to directly interact with and colocalize on centrosomes with the DNA replication factor MCM5 in a CLS-dependent but CDK2-independent manner)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    cervix carcinoma in neoplastic progression
    tumoral     --over  
    in bowenoid papulosis (BP), Bowen disease (BD), skin squamous cell carcinoma (SCC), and basal cell carcinoma (BCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker may be a useful marker to detect cell proliferation in skin tissue sections
    Therapy target
    ANIMAL & CELL MODELS