Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | MCM4 | contributors: mct - updated : 31-03-2012 |
HGNC name | minichromosome maintenance complex component 4 |
HGNC id | 6947 |
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Corresponding disease |
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Location | 8q11.21 Physical location : 48.873.493 - 48.890.068 | ||
Synonym name | |||
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Synonym symbol(s) | CDC21, CDC54, hCdc21, P1-CDC21, MGC33310 |
DNA |
TYPE | functioning gene |
STRUCTURE | 17.96 kb 17 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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motif |
MAPPING | cloned | Y | linked | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | ubiquitous |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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HOMOLOGY |
interspecies | homolog to yeast S.cerevisiae replication Mcm4 (minichromosome maintenance deficient 4) |
intraspecies | homolog to cell division cycle 21(CDC21) |
Homologene |
FAMILY |
CATEGORY | DNA associated |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,organelle,mitochondria | |
intracellular,nucleus,nucleoplasm |
CELLULAR PROCESS | cell life |
nucleotide, replication |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
inhibited by | by CDK2 phosphorylation |
Other | phosphorylation by CDC7 kinase facilitates its interaction with CDC45L on the chromatin |
ASSOCIATED DISORDERS |
corresponding disease(s) | NKGCD |
Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |