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FLASH GENE
Symbol MCM3 contributors: mct/npt/shn - updated : 11-11-2012
HGNC name minichromosome maintenance complex component 3
HGNC id 6945
Location 6p12.2      Physical location : 52.128.811 - 52.149.582
Synonym name
  • cell division cycle, early S-phase-like-3
  • DNA polymerase alpha holoenzyme-associated protein P1
  • DNA replication factor MCM3
  • DNA replication licensing factor MCM3
  • cervical cancer proto-oncogene 5
  • MCM3 minichromosome maintenance deficient 3
  • minichromosome maintenance deficient 3
  • P102 protein
  • RLF subunit beta
  • hRlf beta subunit
  • replication licensing factor, beta subunit
  • Synonym symbol(s) HCC5, MGC1157, P1-MCM3, RLFB, RP1-108C2.3, P1.h, p102
    DNA
    TYPE functioning gene
    STRUCTURE 20.87 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D6S1714 - D6S1956 - MCM3 - D6S1623 - D6S1960 - cen
    Physical map
    LOC389397 6 hypothetical gene supported by BC000383; BC004432; NM_152857 LOC391926 6 similar to 40S ribosomal protein S15a PKHD1 6p12.2 polycystic kidney and hepatic disease 1 (autosomal recessive) IL17 2q31 interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) IL17F 6p12 interleukin 17F SLC25A20P 6p12 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 pseudogene MCM3 6p12 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) C6orf33 6p12.1 chromosome 6 open reading frame 33 EFHC1 6p12.1 EF-hand domain (C-terminal) containing 1 TRAM2 6p21.3 translocation associated membrane protein 2 TMEM14A 6p12.3 transmembrane protein 14A LOC391927 6 similar to class-alpha glutathione S-transferase LOC391928 6 similar to Glutathione S-transferase A1 (GTH1) (HA subunit 1) (GST-epsilon) (GSTA1-1) (GST class-alpha) GSTA2 6p12.2 glutathione S-transferase A2 LOC391929 6 similar to glutathione transferase (EC 2.5.1.18) alpha-3 [similarity] - human GSTA1 6p12.2 glutathione S-transferase A1 GSTAP1 6p12.2 glutathione S-transferase A pseudogene 1 GSTA5 6p12.1 glutathione S-transferase A5 FLJ32293 6p12.3 hypothetical protein FLJ32293 GSTA3 6p12 glutathione S-transferase A3 GSTA4 6p12 glutathione S-transferase A4 RN7SK 6pter-p25 RNA, 7SK, nuclear ICK 6p12.3-p11.2 intestinal cell (MAK-like) kinase FBXO9 6p12.3-p11.2 F-box only protein 9 GCM1 6p21-p12 glial cells missing homolog 1 (Drosophila) LOC389398 6 LOC389398 ELOVL5 6p21.1-p12.1 ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 splicing 3234 91 808 - -
    16 splicing 3121 - 818 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a nuclear localization signal (NLS)
  • a central ATPase/helicase region
  • a phosphorylation sites in the carboxyl terminus that may be sequestered from ATM-dependent checkpoint signals
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae replication Mcm3 (minichromosome maintenance mutant)
    ortholog to Mcm3, Mus musculus
    ortholog to Mcm3, Rattus norvegicus
    ortholog to mcm3, Danio rerio
    ortholog to MCM3, Pan troglodytes
    Homologene
    FAMILY
  • mini-chromosome maintenance (MCM) protein family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • participating in the cell cycle control of genome duplication
  • may represent a glioma-associated antigen with significant prognostic role
  • CDK-dependent MCM3 phosphorylation contributes to the regulated formation of the MCM2-7 complex (Lin 2008)
  • during S phase MCM3 functions as part of the replicative helicase but within the pre-replication, MCM3 is inactive
  • role in controlling the S phase checkpoint of cell cycle
  • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MCM complex is a platform for multiple DNA damage-dependent regulatory signals that control DNA replication
  • INTERACTION
    DNA
  • chromatin
  • RNA
    small molecule
    protein
  • GANP
  • cyclin D1
  • MCM2, MCM4, MCM5, MCM6 and MCM7
  • Rad51 and Rad52
  • ORC2, MCM3, and DTD1 were bound at an ectopic MYC replicator, where deletion of sequences essential for origin activity was associated with the loss of DTD1 binding or the alteration of chromatin structure and loss of MCM3 binding
  • FACT
  • p29
  • MCM binding protein, MCM-BP
  • H4 histone
  • Metaphase Chromosome Protein 1, MCP1
  • Tax oncoprotein
  • cell & other
    REGULATION
    Phosphorylated by cyclin E/Cdk2
    Cdc7
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in astrocytic tumors
    tumoral     --other  
    deregulation might be involved in medulloblastoma tumorigenesis (Lau 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • excess accumulation of MCM3 protein onto chromatin may inhibit DNA replication