basic FUNCTION
| temporarily recruited to the replication sites 30-60 min before they replicate and that it dissociates from chromatin after the activation of the prereplication complex |
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required for forming the pre-initiation complex for initiation of chromosome replication and is involved in the elongation step |
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playing an essential role for the efficient elongation step of chromosome replication |
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being essential for maintaining genome integrity as well as cell cycle progression |
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regulates both replication initiation and elongation and maintains genome integrity  |
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essential eukaryotic protein required for the initiation and elongation phases of chromosomal replication and for the association of several replication proteins, including POLA1, with chromatin  |
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might use a handoff mechanism to load and stabilize POLA1 within the replication fork  |
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required for chromatin loading of WDHD1 and an antibody that disrupts the MCM10-WDHD1 interaction interferes with the loading of WDHD1 and of POLA1, inhibiting DNA synthesis  |