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FLASH GENE
Symbol MCM10 contributors: sge/npt/pgu - updated : 11-01-2010
HGNC name minichromosome maintenance complex component 10
HGNC id 18043
Location 10p13      Physical location : 13.203.553 - 13.253.100
Synonym name
  • homolog of yeast MCM10
  • minichromosome maintenance deficient 10 (S. cerevisiae)
  • Synonym symbol(s) PRO2249, CNA43, MGC126776, DNA43
    DNA
    TYPE functioning gene
    STRUCTURE 49.52 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   transcription factor
    text structure E2F binding motifs
    MAPPING cloned Y linked N status provisional
    Physical map
    USP6NL 10p13 USP6 N-terminal like ECHDC3 10p14 enoyl Coenzyme A hydratase domain containing 3 C10orf47 10p14 chromosome 10 open reading frame 47 UPF2 10p14-p13 UPF2 regulator of nonsense transcripts homolog (yeast) DHTKD1 10p14 dehydrogenase E1 and transketolase domain containing 1 SEC61A2 10p14 dehydrogenase E1 and transketolase domain containing 1 NUDT5 10p14-p13 nudix (nucleoside diphosphate linked moiety X)-type motif 5 C10orf7 10p13 chromosome 10 open reading frame 7 CAMK1D 10p13 calcium/calmodulin-dependent protein kinase ID DKFZP761F241 10p14 hypothetical protein DKFZp761F241 LOC389939 10 similar to ribosomal protein L5 OPTN 10p14 optineurin MCM10 10p13 MCM10 minichromosome maintenance deficient 10 (S. cerevisiae) LOC221044 10p14 hypothetical protein BC018068 PHYH 10p15-p14 phytanoyl-CoA hydroxylase (Refsum disease) SEPHS1 10p14 selenophosphate synthetase 1 C10orf30 10p14 chromosome 10 open reading frame 30 PRPF18 10p12.33 PRP18 pre-mRNA processing factor 18 homolog (yeast) FLJ10210 C10orf45 10p14 chromosome 10 open reading frame 45 LOC283071 10p14 similar to hypothetical protein 9330140G23 HSP70-4 10p14 likely ortholog of mouse heat shock protein, 70 kDa 4 SUV39H2 10p13 suppressor of variegation 3-9 homolog 2 (Drosophila) DCLRE1C 10p14-p13 DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) LOC389940 10 similar to seven transmembrane helix receptor FLJ11106 10p13 hypothetical protein FLJ11106 LOC387634 10 similar to Acyl-CoA-binding protein (ACBP) (Diazepam binding inhibitor) (DBI) (Endozepine) (EP) MGC35468 10p13 hypothetical protein MGC35468 RPP38 10p13 ribonuclease P (38kD)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 4535 98 875 - 2008 17997981
    20 - 4532 - 874 - 2008 17997981
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland    
    Nervousbrain    
    Reproductivemale systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    cell cycle     cell cycle, interphase, S, G2, M, checkpoint, G1S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • zinc finger like motif
  • mono polymer hexamer
    HOMOLOGY
    interspecies homolog to S.cerevisae Mcm10
    homolog to Drosophila Mcm10
    homolog to rattus troponin T
    Homologene
    FAMILY
  • MCM10 family
  • CATEGORY chaperone/stress , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text early to mid-S phase, localized in discrete nuclear foci, in early S phase, several hundred foci appeared throughout the nucleus, in mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions, in the late S and G phases, localized to nucleoli
    basic FUNCTION
  • temporarily recruited to the replication sites 30-60 min before they replicate and that it dissociates from chromatin after the activation of the prereplication complex
  • required for forming the pre-initiation complex for initiation of chromosome replication and is involved in the elongation step
  • playing an essential role for the efficient elongation step of chromosome replication
  • being essential for maintaining genome integrity as well as cell cycle progression
  • regulates both replication initiation and elongation and maintains genome integrity
  • essential eukaryotic protein required for the initiation and elongation phases of chromosomal replication and for the association of several replication proteins, including POLA1, with chromatin
  • might use a handoff mechanism to load and stabilize POLA1 within the replication fork
  • required for chromatin loading of WDHD1 and an antibody that disrupts the MCM10-WDHD1 interaction interferes with the loading of WDHD1 and of POLA1, inhibiting DNA synthesis
  • CELLULAR PROCESS cell cycle, progression
    nucleotide, replication
    nucleotide, genomic integrity
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component MCM10 is a ring-shaped hexamer with large central and smaller lateral channels and a system of inner chambers
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binding to replication factors
  • interacting with POLA1
  • WDHD1 interacts with MCM10, which associates with MCM2-7, and with the p180 subunit of POLA
  • interacting directly with RECQL4 and regulating its unwinding activity
  • MCM10 and CDC45 directly interact and establish a mutual co-operation in DNA binding
  • cell & other
  • binding to nuclease-resistant nuclear structures during S phase exclusively
  • REGULATION
    activated by MYCN
    Other regulated by proteolysis and phosphorylation in a cell cycle-dependent manner
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS