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FLASH GENE
Symbol MCF2 contributors: - updated : 31-12-2004
HGNC name MCF.2 cell line derived transforming sequence
HGNC id 6940
Location Xq26.3-q27.1      Physical location : 138.663.929 - 138.790.381
Synonym name
  • DBL protooncogene,58kDa, diffuse B-cell lymphoma derived
  • RhoA (ARHA) GDP/GTP exchange factor (GEF)
    • Synonym symbol(s) DBL, KIAA0424, PEM2
    DNA
    TYPE functioning gene
    STRUCTURE 60.00 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • a pleckstrin homology (PH)
  • a DBL domains and a SH3 domain
  • a RhoGEF domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to yeast Cdc24
    intraspecies homolog to Ascidian protein posterior End MARK2 (PEM2)
    Homologene
    FAMILY
    CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • GDP-GTP exchange factor for CDC42HS, specifically activating CDC42 and not RAC or RHOA
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS