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FLASH GENE
Symbol MCC contributors: SGE/npt - updated : 07-03-2008
HGNC name mutated in colorectal cancers
HGNC id 6935
Location 5q22.2      Physical location : 112.357.796 - 112.824.527
Genatlas name see TSG5A
Synonym name
  • colorectal mutant cancer protein
  • protein MCC
  • Synonym symbol(s) FLJ38893, FLJ46755, MCC1, DKFZp762O1615
    DNA
    TYPE functioning gene
    STRUCTURE 466.73 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - FER - 3'-
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    MCC-5' - TB2 - 5'- SRP19 -
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    APC-3'- qter
    Authors Kinzler (91)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 8679 - 1019 - Ewing (2007)
  • isoform 1
  • 17 - 8223 - 829 - Ewing (2007)
  • isoform 2
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Nervousbrainforebraincerebral cortex highly
    Skin/Tegumentskin   highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • filamentous coiled coil protein
  • a G protein coupled receptor domain of homology
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • MCC family
  • CATEGORY chaperone/stress , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    text localized on microvilli and in the apical cytoplasm in renal proximal tubule epithelial cells and pancreatic acinar cells
    basic FUNCTION
  • may be involved in cell differentiation
  • may play a role in the signaling pathway negatively regulating cell cycle progression
  • scaffold protein regulating cell movement and able to bind SCRIB, beta-catenin, and SLC9A3R1/SLC9A3R2 (Arnaud 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SCRIB and SLC9A3R1/SLC9A3R2/Ezrin complex in a PDZ-dependent manner (Arnaud 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in several colorectal tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS