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FLASH GENE
Symbol MBP contributors: mct/npt - updated : 19-10-2016
HGNC name myelin basic protein
HGNC id 6925
Corresponding disease
DEL18QD chromosome 18q distal deletion
Location 18q23      Physical location : 74.690.789 - 74.844.774
Synonym name
  • myelin membrane encephalitogenic protein
  • myelin A1 protein
  • Gene in the Oligodendrocyte Lineage-MBP isoform 1
  • genes of the oligodendrocyte lineage-mbp
  • Synonym symbol(s) HMBP, Golli mbp, BG21
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text Golli-MBP gene (10 exons among which 7 constitute MBP gene)
    STRUCTURE 154.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence alternative promoter
    text structure
  • two transcription start sites for Golli-MBP gene
  • MB1 regulatory motif located between nucleotides -14 to -50 plays an important role in transcription of the MBP promoter and the MB1 element contains binding sites for the repressor protein MYEF2
  • MAPPING cloned Y linked Y status confirmed
    Map cen - D18S469 - D18S533 - CYB5 - D18S486 - D18S58 - D18S489 - D18S1121 - D18S380 - D18S844 - MBP - D18S554 - D18S50 - D18S462 - D18S994 - D18S871 - D18S461 - D18S17 - D18S497 - D18S70 - D18S11 - D18S553 - qter
    Authors Strathdee (97)
    Physical map
    FBXO15 18q22.3 F-box only protein 15 HSPC154 18q22.3 HSPC154 protein CYB5 18q23 cytochrome b-5 FAUP1 18 FBR-MuSV-associated ubiquitously expressed (fox derived) pseudogene 1 LOC125704 18q22.3 similar to hypothetical protein B230399E16 CN2 18q22.3 cytosolic nonspecific dipeptidase (EC 3.4.13.18) CN1 18q22.3 carnosinase 1 ZNF407 18q23 zinc finger protein 407 MGC45594 18q22.3 hypothetical protein MGC45594 SDCCAG33 18q22.3 serologically defined colon cancer antigen 33 LOC388482 18 LOC388482 LOC284275 18q23 hypothetical LOC284275 KIAA0222 18q23 hypothetical LOC284275 ZNF236 18q22-q23 zinc finger protein 236 MBP 18q23 myelin basic protein LOC388483 18 LOC388483 GALR1 18q23 galanin receptor 1 LOC390864 18 similar to amino acid feature: Rod protein domain, aa 266 .. 468; amino acid feature: globular protein domain, aa 32 .. 265 LOC125595 18q23 hypothetical LOC125595 LOC390865 18 similar to hypothetical protein LOC390866 18 LOC390866 LOC390867 18 similar to Splicing factor 3A subunit 2 (Spliceosome associated protein 62) (SAP 62) (SF3a66) LOC390868 18 similar to hypothetical protein LOC388484 18 LOC388484 SALL3 18q23 sal-like 3 (Drosophila) ATP9B 18q23 ATPase, Class II, type 9B NFATC1 18q23 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 LOC388485 18 LOC388485 LOC390869 18 similar to immediate early protein homolog LOC147294 18q23 similar to immediate early protein homolog FLJ25715 18q23 hypothetical protein FLJ25715 CTDP1 18q23 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 LOC390870 18 LOC390870 KCNG2 18q22-q23 potassium voltage-gated channel, subfamily G, member 2 FLJ22378 DIM1
    RNA
    TRANSCRIPTS type messenger
    text 14 isoforms produced by alternative splicing
  • classic myelin basic protein (MBP) splice isoforms range in nominal molecular mass from 14 to 21.5 kDa, and arise from the gene in the oligodendrocyte lineage (Golli) in maturing oligodendrocytes (PMID: 23398367)
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1260 21.5 197 - 2014 24321769
  • also called MBP1/21.5kDa
  • inclusion of a 26 residues sequence near the N terminus (from MBP3/18.5 kDa) using the 2nd transcription start site
  • exon-Il-containing MBP isoform 21.5 Kda may regulate cell proliferation via a mechanism that relies on their dynamic nuclear import and export, which is not restricted to the oligodendrocyte lineage
  • 6 splicing 2267 20.2 186 central and peripheral nervous system 2014 24956930
  • using the 2nd transcription start site
  • MBP2/20.2 kDa
  • 5 splicing 2189 17.2 160 central and peripheral nervous system 2014 24956930
  • absence of a 11 AAs sequence near the c terminus from (MBP3/18.5 kda using the 2nd transcription start site
  • MBP4/17.2 kDa
  • 9 splicing 2794 33.1 304 fetal thymus, spleen, spinal cord and immune system 2014 24956930
  • using the first transcription start site 3 additional exons
  • Golli-MBP1/HOG7
  • 7 splicing 2300 26 197 fetal thymus, spleen, spinal cord and immune system 2014 24956930
  • Golli MBP2/HOG5
  • using the first transcription start site exons 1b-7
  • 6 splicing 2222 18.5 171 central and peripheral nervous system 2014 24956930
  • using the 2nd transcription start site
  • MBP3/18.5 kDa
  • association of the predominant 18.5-kDa MBP isoform with cytoskeletal and signaling proteins in primary oligodendrocytes
  • - splicing - 28 - tissues hematopoietic brain 2014 24956930
    exons 1A-1B
    - - 4889 - 197 - 2014 24956930
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Endocrinepancreas   moderately
    Nervous    predominantly
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Skin/Tegumentskin   highly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoligodendrocyte
    cell lineage myeloid lineage cells
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text thymus, spleen, spinal cord
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
    conjugated PhosphoP , Other
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Mbp
    Homologene
    FAMILY
  • myelin basic protein family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing a role in nerve function and in formation and stabilization of the myelin membrane
  • may play a role in regulating the deposition of Abeta42 and thereby also may regulate the early formation of amyloid plaques in Alzheimer's disease (Hoos 2009)
  • play roles in myelination and T cell activation pathways (Ahmed 2007)
  • acting synergistically with PMP2 to cause stacking of lipid bilayers (Suresh 2010)
  • function as a new type of modulator of intracellular Ca(2+) levels in oligodendrocyte progenitor cells (OPCs)
  • the only known structural protein required for formation of myelin, produced by oligodendrocytes in the central nervous system, is myelin basic protein (MBP)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , immunity/defense , nervous system
    text central nervous system development
    PATHWAY
    metabolism
    signaling neurotransmission
    synaptic transmission
    a component
  • major constituent of normal myelin of central nervous system
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specific interaction between HSPA4 and MBP suggestive of a possible role for HSPA4 in the immunopathology associated with multiple sclerosis (Lund 2006)
  • interacting with OLIG1 and SOX10 (OLIG1 and SOX10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes) (Li 2007)
  • interaction of calmodulin with a C-terminal segment of MBP (Majava 2008)
  • regulates SOCE (store-operated Ca(2+) entry) in T-cells and oligodendrocyte precursor cells
  • binds to STIM1-ORAI1 complexes to negatively regulate the activity of SOCCs (store-operated Ca(2+) channels)
  • RNA-binding protein HNRNPF is a novel component of MBP mRNA transport granules
  • HNRNPF is a regulatory element of MBP expression in oligodendrocytes, suggesting an important function of HNRNPF in the control of myelin synthesis
  • DDX54 may directly interact with MBP mRNA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL18QD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in multiple sclerosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS