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FLASH GENE
Symbol MBLAC1 contributors: mct - updated : 16-10-2019
HGNC name metallo-beta-lactamase domain containing 1
HGNC id 22180
Location 7q22.1      Physical location : 99.724.319 - 99.726.119
Synonym symbol(s) MGC39819
EC.number 3.-.-.-
DNA
TYPE functioning gene
STRUCTURE 1.78 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1226 - 266 - 2018 30507380
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to C-Elegans swip-10
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
text
  • presence of MBLAC1 in both the cytosol and nucleus
  • basic FUNCTION
  • is selective for 3 prime processing of Replication-dependent (RD) histone pre-mRNA during the S-phase of the cell cycle
  • is a new type of S-phase-specific cancer target, with a specific role for MBLAC1 during S-phase
  • is a nuclease specific for cleavage of RD histone pre-mRNA
  • both MBLAC1 and, as expected, CPSF3 depleted cells are impaired in efficiently entering/progressing in S-phase
  • specific role for MBLAC1 in cell cycle regulation, in particular on entering/progressing through S-phase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • is predominantly dimeric, the active site variant is mainly monomeric
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a specific, high-affinity target for the glutamate transporter inducer ceftriaxone
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may represent a new S-phase specific cancer target
    ANIMAL & CELL MODELS