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FLASH GENE
Symbol MAZ contributors: mct - updated : 09-03-2018
HGNC name MYC-associated zinc finger protein (purine-binding transcription factor)
HGNC id 6914
Location 16p11.2      Physical location : 29.817.854 - 29.822.502
Synonym name
  • ZIF87,serum amyloid activating factor 2
  • transcription factor Zif87
  • zinc finger protein 801
  • zinc-finger protein, 87 kilodaltons
  • serum amyloid A activating factor 1
  • Synonym symbol(s) PUR1, ZF87, SAF2, SAF1, Zif87, ZNF801
    DNA
    TYPE like-sequence
    STRUCTURE 5.10 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    MAPPING cloned Y linked   status confirmed
    Map pter - D16S3093 - KIF22 - MAZ - D16S409 - cen
    Authors GeneMap 98 (NCBI)
    Physical map
    LOC388241 16 similar to PI-3-kinase-related kinase SMG-1 isoform 2; lambda/iota protein kinase C-interacting protein; phosphatidylinositol 3-kinase-related protein kinase MGC5178 16p12.1 hypothetical protein MGC5178 LOC388242 16 similar to hypothetical protein BC011981 KIAA0220 16p12.1 KIAA0220 protein LAT1-3TM 16p12 LAT1-3TM protein LOC388243 16 similar to carbonic anhydrase VA, mitochondrial precursor; carbonic anhydrase V, mitochondrial; carbonic dehydratase SPN 16p11.2 sialophorin (gpL115, leukosialin, CD43) QPRT 16q13 quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating)) FLJ35681 16p12.1 hypothetical protein FLJ35681 ZG16 16p12.1 zymogen granule protein 16 KIF22 16p11.2 kinesin family member 22 MAZ 16p11.2 MYC-associated zinc finger protein (purine-binding transcription factor) LOC112476 16p12.1 similar to lymphocyte antigen 6 complex, locus G5B; G5b protein; open reading frame 31 MGC4606 16p12.1 hypothetical protein MGC4606 MVP 16p11.2 major vault protein CDIPT 16p12.1 CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) PSK-1 16p12.1 type I transmembrane receptor (seizure-related protein) KCTD13 16p11.2 potassium channel tetramerisation domain containing 13 LOC253982 16p12.1 hypothetical protein LOC253982 LOC124446 16p12.1 hypothetical protein BC017488 PSK 16p12.1 hypothetical protein BC017488 TAO1 16p11.2 hypothetical protein BC017488 HIRIP3 16q13 HIRA interacting protein 3 FLJ90652 16p12.1 hypothetical protein FLJ90652 DOC2A 16q13 double C2-like domains, alpha DKFZP434I2117 16p12.1 hypothetical protein DKFZp434I2117 ALDOA 16q22.2 aldolase A, fructose-bisphosphate PPP4C 16p12-p11 protein phosphatase 4 (formerly X), catalytic subunit TBX6 16p11.2 T-box 6 MGC10500 16p12.1 hypothetical protein MGC10500
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 2559 48 477 - 2017 28577976
  • Variant 1 / SAF-1
  • during many inflammatory conditions, protein level remains unchanged
  • also called SAF-1
  • 6 splicing 2784 51 493 - 2017 28577976
  • Variant 1 / SAF-2
  • the C terminus of SAF-2 containing two additional zinc fingers is different from SAF-1
  • the level of protein is reduced during many inflammatory conditions
  • acting as a regulator of transcription
  • 6 - 2374 - 454 - 2017 28577976
    3 - 1644 - 172 - 2017 28577976
    EXPRESSION
    Type ubiquitous
    constitutive ofhousekeeping
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six zinc fingers of the C2H2 type
  • a N terminal proline-rich domain
  • several polyalanine tracts
  • two distinct but adjacent domains in MAZ are involved in protein-protein contact with FOS and JUN
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Maz (98,59 pc)
    Homologene
    FAMILY
    CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • growth suppressor in non transformed cells by affecting the levels of key cell cycle regulatory proteins
  • may function as a transcription factor with dual roles in transcription initiation and termination
  • plays a key role in the development of AA amyloidosis, a consequence of chronic inflammation
  • essential role of MAZ and JUN in up-regulating human MMP1 expression under various inflammatory conditions
  • is a hitherto unrecognized participant in inducing VEGFA expression in triple-negative breast cancer cells, an aggressive form of breast cancer that currently lacks effective treatment options
  • plays a key role in regulation of gene expression and tumor development
  • MAZ can promote the invasion and metastasis of hepatocellular carcinoma (HCC) by inducing epithelial-mesenchymal transition (EMT)
  • CELLULAR PROCESS nucleotide, transcription, initiation
    nucleotide, transcription, termination
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • binding
  • RNA
    small molecule
    protein
  • cMYC (repression of)
  • KLF15 and CLCKNA (blocking activating effect of MAZ)
  • inflammation responsive transcription factors JUN and MAZ synergistically regulate transcriptional induction of the MMP1 gene
  • MAZ and AR are interrelated and MAZ plays an important role in Prostate cancer (PCa) pathogenesis
  • SPIN1 directly enhances expression of GDNF, an activator of the RET signaling pathway, in cooperation with the transcription factor MAZ
  • MAZ plays an important role in ADAM10 transcription in response to CTF1 in neural progenitor cells
  • is a transcription factor with C2H2-type zinc-finger motifs that can bind GC-rich cis-elements
  • FOXF2 is a novel transcription target of MAZ and mediates the functions of MAZ
  • MAZ is essential to bypass MYB promoter repression by RB1 family members and to induce MYB expression
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • MAZ mRNA level, particularly in combination with the FOXF2 mRNA level, may serve as a prognostic marker for basal-like breast cancer (BLBC) patients
  • Therapy target
    ANIMAL & CELL MODELS