| basic FUNCTION
| involved in the differentiation state of chondrocytes |
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playing with COMP an important role in matrix assembly |
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may play a role in the formation of extracellular filamentous networks |
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have a role in the development and homeostasis of cartilage and bone |
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mediate cell attachment, but the binding is clearly dose dependent and seen already at moderate coating concentrations  |
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oligomeric extracellular matrix adaptor proteins mediating interactions between collagen fibrils and other matrix constituents |
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MATN1 and MATN3 modulate collagen fibrillogenesis in cartilage and provide evidence that biochemical compensation might exist between matrilins |
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activates the expression of osteoarthritis-associated genes in primary human chondrocytes |
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proteolytically-released MATN3 induces pro-inflammatory cytokines and ADMATS4/5 (via IL1-beta) which in turn cleave MATN3 and may release more MATN3 from the matrix |
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function for MATN1 and MATN3 to maintain and enhance chondrogenesis of mesenchymal fibroblasts initiated by TGF-beta |
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possible roles for MATN1/MATN3 hetero-oligomers could be to further bring this collagen type II and IX integrated meshwork together by increasing their affinities to interact with the extracellular matrix |
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MATN1, MATN2, MATN3, MATN4 are important to protect articular cartilage from deterioration and are involved in the specification of the vertebral column |
