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FLASH GENE

Symbol

MATK

contributors: mct - updated : 06-09-2010

HGNC name	megakaryocyte-associated tyrosine kinase
HGNC id	6906

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.3      Physical location : 3.777.967 - 3.801.810
Synonym name	CSK homologous kinase
	tyrosine-protein kinase CTK
	protein kinase HYL
	hematopoietic consensus tyrosine-lacking kinase
	tyrosylprotein kinase
	hydroxyaryl-protein kinase
	Csk-type protein tyrosine kinase
	HYL tyrosine kinase
	tyrosine kinase MATK
	leukocyte carboxyl-terminal src kinase related
Synonym symbol(s)	HYLTK, CTK, HYL, Lsk, CHK, HHYLTK, DKFZp434N1212, MGC1708, MGC2101
EC.number	2.7.10.2

DNA

TYPE	functioning gene
STRUCTURE	23.84 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_139355 14 - 2163 NP_647612 56.3 507 - Avraham (1995) NM_002378 14 - 2104 NP_002369 56.8 508 - Avraham (1995) NM_139354 13 - 1940 NP_647611 51.9 466 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Nervous brain       highly Respiratory lung         Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic megakaryocyte Nervous neuron

cell lineage	myeloid cell lines
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal unique domain involved in nuclear localization and MATK-induced tyrosine phosphorylation in the nucleus (Nakayama 2005)
	SH3 domains, SH2 and SRC homology domains, that may bind to different phosphoproteins, providing a basis for different cellular functions for CSK and MATK (Ayrapetov 2005)

HOMOLOGY

interspecies

homolog to murine Matk

Homologene

FAMILY	protein kinase superfamily
	Tyr protein kinase family
	CSK subfamily

CATEGORY

enzyme , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	localizes to the nucleus as well as the cytoplasm and inhibits cell proliferation (Nakayama 2006)
	associated with the nucleus and the nuclear matrix (Nakayama 2006)

basic FUNCTION	hematopoietic consensus tyrosine-lacking kinase
	phosphorylates Src-family tyrosine kinases and suppresses their kinase activity (Nakayama 2005)
	nuclear multi-lobulation in late S phase, dependent on polymerization and depolymerization of microtubules, may be involved in nuclear MATK-induced inhibition of proliferation (Nakayama 2005)
	nuclear tyrosine-phosphorylated protein that may contribute to inhibition of cell proliferation (Nakayama 2006)
	not functionally redundant with CSK, and this tyrosine kinase plays an important role as a regulator of immunologic responses (Lee 2006)
	endogenous inhibitor of Src protein tyrosine kinases (Belot 2007)
	can inhibit the kinase activity of certain Src kinase family members by phosphorylating the C-terminal tyrosine and by a non-catalytic mechanism (Zhu 2008)
	suppresses anchorage-independent cell growth and cell invasion of colon cancer cells, having potentially important role in Src activation and tumorigenicity in colon cancer cells (Zhu 2008)
	potentially capable of inhibiting the CXCL12-CXCR4 pathway in neuroblastoma (Zagozdzon 2008)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

physiological inhibitor of CXCR4 expression (Zagozdzon 2008)

cell & other

REGULATION

induced by

progesterone (progesterone increases the amount of MATK, which in turn reduces HMC-1(560) mast cell proliferation)(Belot 2007)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS