Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MAS1 contributors: mct - updated : 07-12-2011
HGNC name MAS1 oncogene
HGNC id 6899
Location 6q25.3      Physical location : 160.327.973 - 160.329.105
Synonym name angiotensin receptor
Synonym symbol(s) MGC119966, MAS, Ang-(1-7)/MAS
DNA
TYPE functioning gene
STRUCTURE 1.13 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • promoter had the potential to be repressed by the human HMG box containing protein
  • SRY (hSRY) binding sites for ZNF274, TRIM28, SP1 and HDAC2
  • proximal promoter of MAS contains numerous potential SOX binding elements (
  • MAPPING cloned Y linked N status confirmed
    Physical map
    TCTEL1 6q25.2-q25.3 t-complex-associated-testis-expressed 1-like 1 SYTL3 6q25.3 synaptotagmin-like 3 VIL2 6q25-q26 villin 2 (ezrin) LOC389439 6 LOC389439 LOC202459 6q25.3 similar to RIKEN cDNA 2310008M10 LOC389440 6 LOC389440 LOC346064 6q25.3 similar to SNARE protein Ykt6; YKT6, S. cerevisiae, homolog of RSHL2 6q25.3 radial spokehead-like 2 TAGAP 6q25.3 T-cell activation GTPase activating protein LOC389441 6 LOC389441 LOC389442 6 LOC389442 LOC389443 6 LOC389443 LOC389444 6 similar to frazzled CG8581-PA FNDC1 6q25 fibronectin type III domain containing 1 LOC389445 6 similar to 60S ribosomal protein L21 SOD2 6q25.2 superoxide dismutase 2, mitochondrial WTAP 6q25-q27 Wilms tumor 1 associated protein ACAT2 6q25.3-q26 acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) TCP1 6q25.1-q25.2 t-complex 1 MRPL18 6q25.3 mitochondrial ribosomal protein L18 PNLDC1 6q25.3 poly(A)-specific ribonuclease (PARN)-like domain containing 1 MAS1 6q25.3-q26 MAS1 oncogene IGF2R 6q26-q27 insulin-like growth factor 2 receptor SLC22A1 6q27 solute carrier family 22 (organic cation transporter), member 1 SLC22A2 6q26-q27 solute carrier family 22 (organic cation transporter), member 2 SLC22A3 6q26-q27 solute carrier family 22 (extraneuronal monoamine transporter), member 3 APOAL 6q26-q27 apolipoprotein A-like LPA 6q26-q27 lipoprotein, Lp(a) PLG 6q26 plasminogen LOC389446 6 similar to apolipoprotein(a) (EC 3.4.21.-) - rhesus macaque (fragment) LOC389447 6 LOC389447 MAP3K4 6q25.3 mitogen-activated protein kinase kinase kinase 4 AGPAT4 6q25.3 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) C6orf59 6q25.3 chromosome 6 open reading frame 59
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1135 37.33 325 - 1997 9441760
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebrain    Mus musculusAdult
     brainlimbic systemhippocampus   Mus musculusAdult
    Olfactory (smell)olfactory bulb     Mus musculusAdult
    Reproductivefemale systemovary    Homo sapiens
     male systemtestis    Mus musculusAdult
    Urinarykidney     Mus musculusAdult
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegranulosa cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY protooncogene , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects
  • ability of MAS1 to up-regulate AGTR1 levels reflects the constitutive capacity of MAS1 to activate GNA11 and hence stimulate PKC-dependent phosphorylation of the AGTR1
  • key role for the Ang-(1-7)/MAS1 axis as a modulator of cardiomyocyte function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • Ang-(1-7)/MAS1 axis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • stimulation of the MAS1 protein should result in increased nitric oxide, potentially nitrating the ZNF274/TRIM28 complex, resulting in dissociation of TRIM28 and activation of the transcription of MAS1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS