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FLASH GENE
Symbol MARVELD1 contributors: mct - updated : 01-06-2021
HGNC name MARVEL domain containing 1
HGNC id 28674
Location 10q24.2      Physical location : 99.473.464 - 99.477.909
Genatlas name
  • MAL (The myelin and lymphocyte protein) and related proteins for vesicle trafficking and membrane link] domain containing 1
  • Synonym name
  • MARVEL (membrane-associating) domain containing 1
  • putative MARVEL domain-containing protein 1
  • Synonym symbol(s) FLJ22343, FLJ23440, GB14, MARVD1, MGC4415, MRVLDC1, bA548K23.8, RP11-548K23.8
    DNA
    TYPE functioning gene
    STRUCTURE 4.43 kb     2 Exon(s)
    MAPPING cloned N linked Y status
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3250 - 173 - 2011 21347699
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • MARVEL domain
  • HOMOLOGY
    Homologene
    FAMILY
  • MARVEL domain family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • is located in nucleus instead of cell membrane
  • observed in the nucleus and at the perinuclear region during interphase, but was localized at the mitotic spindle and midbody at metaphase, and a significant fraction of MARVELD1 translocated to the plasma membrane during anaphase
  • basic FUNCTION
  • down-regulated in multiple cancers and silenced by DNA methylation (Wang 2009)
  • is a microtubule-associated protein that plays an important role in cell cycle progression and migration
  • could suppress cell spreading and complicate actin organization
  • plays a role in pre-mRNA processing of integrin beta1, and thereby regulates cell adhesion and cell motility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MARVELD1 promotes the dissociation of SMG1 from UPF1, resulting in the repression of serine phosphorylation of UPF1
  • MARVELD1 regulated neuronal migration by mediating the formation of glial fibres and ITGB1/PTK2 signalling pathway
  • MARVELD1 interacting with catalase regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    d in primary multiple tumors derived from ovary, vulva, uterus, cervix, breast, testis, kidney, bladder and liver
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • MARVELD1 silencing is an appealing diagnostic biomarker for lung cancer and epigenetic silencing of MARVELD1 gene links with the regulatory mechanism of NMD pathway in lung cancer, which may be required for tumorigenesis
  • Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    has a potential to be developed as a therapeutic target for NSCLC
    ANIMAL & CELL MODELS
  • Marveld1-defected mice displayed motor and cognitive dysfunction resulting from aberrant neuronal migration during brain development