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Symbol MARK2 contributors: mct/pgu - updated : 04-08-2012
HGNC name MAP/microtubule affinity-regulating kinase 2
HGNC id 3332
Location 11q13.1      Physical location : 63.606.399 - 63.678.491
Synonym name
  • ELKL motif kinase
  • murine Emk1 (ELKL Motif Kinase) homolog
  • protein-serine/threonine kinase
  • Ser/Thr protein kinase PAR-1B
  • PAR1 homolog
  • partitioning-defective 1 b
  • serine/threonine kinase
  • Synonym symbol(s) D11S1226, EMK1, PAR-1, Par1b, MGC99619
    TYPE functioning gene
    STRUCTURE 70.16 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    TMSL5 11 thymosin-like 5 RARRES3 11q23 retinoic acid receptor responder (tazarotene induced) 3 HRASLS2 11q13.1 HRAS-like suppressor 2 HRASLS3 11q13.1 HRAS-like suppressor 3 LOC283241 11q13.1 hypothetical protein LOC283241 DKFZP564J0863 11q13.1 DKFZP564J0863 protein RTN3 11q13 reticulon 3 LOC144097 11q13.1 hypothetical protein BC007540 MARK2 11q12-q13 MAP/microtubule affinity-regulating kinase 2 LOC283248 11q13.1 hypothetical protein LOC283248 FLJ13848 11q13.1 hypothetical protein FLJ13848 COX8 11q13.1 cytochrome c oxidase subunit VIII OTUB1 11q13.1 OTU domain, ubiquitin aldehyde binding 1 LRP16 11q11 LRP16 protein LOC387776 11 LOC387776 FLRT1 11q12-q13 fibronectin leucine rich transmembrane protein 1 STIP1 11q13.2 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) URP2 11q13.1 UNC-112 related protein 2 short form
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2784 77.5 691 - 1998 9730619
    19 - 2965 83 745 - 1998 9730619
    18 - 4556 81.07 724 - 1998 9730619
    18 - 4748 - 788 - 1998 9730619
    - - 4541 - 719 - 1998 9730619
    - - 4511 - 709 - 1998 9730619
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Nervousbrain   highly
    Reproductivefemale systemuteruscervix highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    at STAGE
  • ubiquitin-associated domain (UBA) domain, attached via a taut linker to the large lobe of the kinase domain and leans against a hydrophobic patch on the small lobe
  • mono polymer homomer , dimer
    interspecies homolog to murine Emk1 (ELKL Motif Kinase)
  • Par-1 protein kinases family
  • CAMK Ser/Thr protein kinase family
  • microtubule affinity-regulating kinase (MARK)/Par-1 family
  • CATEGORY enzyme , receptor membrane serine/threonine
        plasma membrane
    text membrane accumulation of MARK2 induced by DVL1L1 is regulated by its phosphorylation status, which is important for MARK2 to regulate the microtubule dynamics
    basic FUNCTION
  • potentially involved in the control of cell polarity
  • involved in microtubule stability and cancer
  • adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway
  • phosphorylates tau protein at sites that cause detachment from microtubules in Alzheimer neurofibrillary degeneration
  • conserved kinase that plays crucial roles in cell polarity
  • specifically regulates development of dendrites in hippocampal neurons
  • with MARK3, phosphorylate class IIa HDACs on one of their multiple 14-3-3 binding sites and alter their subcellular localization and repressive function
  • negatively regulates dendrite development through phosphorylation of MAP2
  • MARK1, MARK2, MARK3, MARK4 phosphorylate MAPT in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments
  • regulates axon formation via phosphorylation of a kinesin superfamily protein KIF13B
  • potentially a positive regulator for lipogenesis in adipocytes and hepatocytes
  • plays key roles in the development of cell polarity
  • may contribute to cell polarization by regulating the turnover of ARHGEF2 at microtubules
  • appears to regulate cell polarization via several microtubule-associating proteins, such as KIF13B and ARHGEF2
  • is thought to regulate microtubule dynamics by inhibiting microtubule binding of microtubule-associated proteins
  • potential novel function in the maintenance of mature dendritic spine morphology by regulating microtubule growth and the accumulation of SRCIN1 in dendritic spines
  • ROCK1/MARK2-dependent regulation of basement membrane placement is required for the coordination of tissue polarity and the elaboration of tissue structure in the developing submandibular salivary gland
  • MARK1, MARK2, MARK3, MARK4 are implicated in phosphorylation of tau protein, causing formation of neurofibrillary tangles in Alzheimer disease (AD)
    a component
    small molecule
  • interacts with CDK16
  • binds to the C-terminal part of WEE1
  • interacts with SSH1
  • interacting with FLOT2 (binds to MARK2, a known upstream mediator of major signal transduction pathways implicated in cell growth and metastasis, and may thereby influence tumor progression)
  • MARK2 is negatively regulated by PAK7, a neuronal member of the p21-activated kinase family
  • RAB11FIP2 is phosphorylated on serine 227 by MARK2, regulating an alternative pathway modulating the establishment of epithelial polarity
  • substrate for ARHGEF2
  • GAB1 brings MARK2 and PARD3 into a transient complex, stimulating PARD3 phosphorylation by MARK2
  • increase in MAPT phosphorylation at Ser262 through MARK2 contributes to MAPT-mediated neurodegeneration under a pathological condition in which axonal mitochondria is depleted
  • cell & other
    Other regulated by atypical protein kinase C (aPKC) and another arm of the PKC pathway, one that involves novel PKCs (nPKC) and protein kinase D
    regulated by 14-3-3 scaffolding proteins, as well as the LKB1 tumour suppressor kinase and atypical protein kinase C (PKC)
    corresponding disease(s)
    Variant & Polymorphism
    Candidate gene
    Therapy target
  • in Par-1b null mice, decrease in the adipose tissue due to decreases in total adipocyte cell number, not cell size
  • Par-1b/Par-1a double mutants are not viable, and at least one allele is necessary for embryonic survival