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FLASH GENE
Symbol MARCKSL1 contributors: mct - updated : 27-04-2015
HGNC name MARCKS-like 1
HGNC id 7142
Location 1p35.1      Physical location : 32.799.440 - 32.801.834
Synonym name
  • myristoylated alanine-rich protein kinase C substrate (MARCKS) like protein
  • MARCKS-like protein
  • Synonym symbol(s) MACSL1, F52, MacMARCKS, MLP1, MLP, MRP
    DNA
    TYPE functioning gene
    STRUCTURE 2.41 kb     2 Exon(s)
    MAPPING cloned   linked   status provisional
    Map pter - D1S511 - [MARCKSL1 ] - D1S2417 - cen
    Authors Schuler (96)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1562 - 195 - 1998 9598313
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyeretina    Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a positively charged effector domain (ED) , that binds F-actin, Ca2+-calmodulin, and acidic phospholipids
  • HOMOLOGY
    Homologene
    FAMILY MARCKS family of phospholipid binding proteins
    CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • after phosphorylation, is relocated to the intracellular membranes of late endosomes and lysosomes
  • basic FUNCTION
  • myristoylated alanine-rich protein, may be involved in development of central nervous system
  • plays a role in regulating retinal cell proliferation
  • MARCKS and MARCKSL1 are membrane-binding proteins implicated in cell spreading, integrin activation and exocytosis
  • role for MARCKSL1 in adherens junction formation and tumorigenesis
  • membrane-bound protein that is associated with cell spreading, integrin activation and exocytosis
  • modulator in the regulation of cellular homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a LOXL2 interacting protein (scavenger-receptor domain of LOXL2 was shown to interact with the N-terminal domain of MARCKSL1)
  • CALM1 and CAMK2A modulate SCNN1A activity by destabilizing the association between the actin cytoskeleton, SCNN1A, and MARCKS, or MARCKSL1 at the apical membrane
  • cell & other
    REGULATION
    repressed by ITGB3 (downregulation by ITGB3 is not required for increased cell spreading but instead is a secondary effect of increased cell spreading)
    Phosphorylated by MAPK8 and MAPK8 phosphorylation of MARCKSL1 regulates actin homeostasis, filopodium and lamellipodium formation, and neuronal migration under physiological conditions
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in lymph node-negative breast cancer with good survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS