SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microfilament
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| text
| binding actin filaments when not phosphorylated |
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presence of MARCKS in plasmalemmal caveolae and/or lipid rafts |
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localized to the nucleus  |
| basic FUNCTION
| actin filament crosslinking protein regulator of actin cytoskeleton |
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MARCKS and MARCKSL1 are membrane-binding proteins implicated in cell spreading, integrin activation and exocytosis |
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play a major key role in PDGF-BB-induced chemotaxis in activated hepatic stellate cells |
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directly involved in dendrite branching during neurogenesis and mediates the regulation of the actin cytoskeleton at particular cortical cell regions where filopodia are being formed |
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participate in formation of F-actin-based lamellipodia, which represents the first stage of neurite formation |
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may be having a novel role in lamellipodia formation induced by IGF1 via the translocation of MARCKS, and accumulation of beta-actin in the membrane microdomains |
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plays a key role in insulin-dependent endothelial signaling to PIP2 and is a critical determinant of actin assembly and directed cell movement in the vascular endothelium |
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critical determinant of insulin-modulated PIP2 responses in endothelial cells, and having a key role in WASL/Arp2/3 signaling in endothelial cells |
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may potentially play a role in vascular disease states characterized by deficient endothelium-dependent signaling responses |
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distinct role for MARCKS in the regulation of H2O2-induced permeability change in endothelial cells |
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is a mediator of the H2O2-induced endothelial permeability change, but does not modulate changes in basal permeability |
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regulates endothelial permeability and cytoskeleton organization |
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important functional role for the interaction between MARCKS and PSA in the developing and adult nervous system |
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actin-binding protein, with special functions in the development of the central nervous system |
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might also be important for the differentiation of of PNS cells and precursors |
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is a negative modulator of the acrosomal exocytosis, probably by sequestering PIP2, and it is phosphorylated during acrosomal exocytosis |
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novel function of MARCKS in mediating membrane targeting of plasmalemmal precursor vesicles (PPVs) during axon development |
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is postulated to regulate the passage of secretory granules through cortical actin in the early phase of exocytosis |
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appears to be a nonessential regulatory protein in mast cell exocytosis but exerts a negative modulation |
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PRKCD-mediated MARCKS phosphorylation as a key step in the inflammatory response of neutrophils |
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is a novel translational target with beneficial cell type-specific effects on both endothelial cell (EC) and vascular smooth muscle cell (VSMC) |
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acts as a "molecular switch," binding to and regulating PIP2 signaling to regulate processes like proplatelet extension (microtubule-driven) vs proplatelet branching (Arp2/3 and actin polymerization-driven) |
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is enriched in the developing brain and plays an important, phosphorylation-dependent role in the modulation of axonal growth cone adhesion |
