SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,organelle,lysosome
|
| intracellular,cytoplasm,cytosolic,vesicle
|
| intracellular,nucleus
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basic FUNCTION
| functioning as an E3 ubiquitin ligase for immune recognition-related molecules (e.g. major histocompatibility complex class I, B7-2, and ICAM-1) |
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inducing specific down-regulation of B7-2 surface expression through ubiquitination (molecular interaction is necessary), rapid endocytosis, and lysosomal degradation of the target molecule |
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role of MARCH8 and MARCH4 in the regulated turnover of CD81 and CD44, two ubiquitously expressed, multifunctional proteins |
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involved direct ubiquitination of SLC3A2 and routing of SLC3A2 to late endosomes/lysosomes |
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MARCH E3 ligases play a key role in controlling MHC class II surface expression by regulated ubiquitination of a lysine residue in the beta-chain |
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MARCHF8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection |
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MARCHF8 reduces viral infectivity by downregulating envelope glycoproteins through two different mechanisms mediated by a ubiquitination-dependent or tyrosine motif-dependent pathway |
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MARCHF1 and MARCHF8 are ubiquitin ligases that control the expression and trafficking of critical immunoreceptors |
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tissue-specific functions of MARCHF1 and MARCHF8 in regulation of immune receptor expression |