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FLASH GENE
Symbol MARCHF3 contributors: mct/npt - updated : 08-02-2023
HGNC name membrane-associated ring finger (C3HC4) 3
HGNC id 28728
Location 5q23.2      Physical location : -
Synonym name
  • RING finger protein 173
  • membrane-associated RING-CH protein III
    • Synonym symbol(s) MGC48332, MARCH-III, RNF173, FLJ20096, MARCH3
    EC.number 6.3.2.-/ 2.3.2.27
    DNA
    TYPE functioning gene
    STRUCTURE 163.30 kb     5 Exon(s)
    motif
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4158 - 253 - 2016 27616439
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Lymphoid/Immunespleen   highly
    Respiratorylung   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short N terminus
  • a RING-CH domain
  • two transmembrane domains
    • HOMOLOGY
    Homologene
    FAMILY
  • MARCH family (membrane-bound E3 ubiquitin ligases)
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    text present in peripheral vesicles partially colocalized with transferrin receptor (Fukuda 2006)
    basic FUNCTION
  • may be involved in the regulation of vesicular trafficking in endosomes (Fukuda 2006)
  • MARCHF3 is likely a pivotal negative regulator of IL6-induced STAT3 activation, inflammation, and inflammation-associated carcinogenesis
  • MARCHF2 and MARCHF3 play redundant roles in targeting IL5RA for degradation and negatively regulating allergic airway inflammation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with (syntaxin 6) STX6 and MARCH2
  • MARCH3 negatively regulates STAT3 activation triggered by IL6, as well as another IL6 subfamily member, Oncostatin M
  • MARCHF2 and MARCHF3 are critical negative regulators of IL5-triggered signaling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in human colorectal cancer tissues and associated with poor survival across different cancer types
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS