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FLASH GENE
Symbol MARCHF2 contributors: mct/npt - updated : 08-02-2023
HGNC name membrane associated ring-CH-type finger 2
HGNC id 28038
Location 19p13.2      Physical location : -
Synonym name
  • membrane-associated RING-CH protein II
  • RING finger protein 172
  • membrane-associated ring finger (C3HC4) 2
  • Synonym symbol(s) RNF172, HSPC240, MARCH-II, MARCH2
    EC.number 6.3.2.-/ 2.3.2.27
    DNA
    TYPE functioning gene
    STRUCTURE 25.71 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1705 - 246 - 2020 32935379
    5 - 1434 - 246 - 2020 32935379
    4 - 1224 - 176 - 2020 32935379
    5 - 2025 - 246 - 2020 32935379
    6 - 1649 - 246 - 2020 32935379
    6 - 1446 - 246 - 2020 32935379
    5 - 1720 - 246 - 2020 32935379
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
     thyroid   highly
    cell lineage
    cell lines
    fluid/secretion lymph, highly
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a ring-type zinc finger
  • a PDZ ligand motif of MARCH2 participates in recognition and binding to the PDZ domain protein DLG1
  • HOMOLOGY
    intraspecies homolog to MARCH3
    Homologene
    FAMILY
  • E3 ubiquitin ligase family, MARCH family E3 ligases
  • small family of RING-CH ligases
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    text
  • localized to endosomal vesicles and the plasma membrane
  • often associated with endosomal membranes
  • basic FUNCTION
  • plays a role in endosomal protein transport (Fukuda 2006)
  • regulator of trafficking between the trans-Golgi network and endosomes, which is a novel function for the MARCH family
  • MARCH2 displays direct binding with STX6 and has been shown to regulate Transferrin receptor trafficking
  • is mainly associated with the vesicle trafficking
  • likely an important role for MARCH2 in homeostatic control of innate immune responses
  • MARCHF2 and MARCHF3 play redundant roles in targeting IL5RA for degradation and negatively regulating allergic airway inflammation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding partner of syntaxin 6 (Fukuda 2006)
  • interacting with DLG1 (anchor for the E3 ligase MARCH2 at sites of cell-cell contact) (Cao 2008)
  • MARCH2 catalytic activity is not required for its interaction with the ADRB2 and loss of activity creates a “substrate trap” leading to a stable complex formation between the two molecules
  • ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins GOPC and STX6
  • MARCH2 interacts with CFTR (cystic fibrosis transmembrane conductance regulator), promotes the ubiquitination and degradation of CFTR, and inhibits CFTR-mediated autophagy in tumor cells (
  • MARCH2 restricts cytosolic pools of DVL protein and reduces the need for WNT signaling in precise vertebrate head development
  • inhibits the production and infection of HIV-1 through ligase activity-dependent envelope protein degradation and/or intracellular retention
  • MARCHF2-mediated ERGIC3 ubiquitination is the major cause of the decrease in trafficking of ERGIC3-binding secretory proteins
  • MARCHF2 is a novel negative regulator of IKBKG-mediated signaling upon bacterial or viral infection
  • MARCHF2 and MARCHF3 are critical negative regulators of IL5-triggered signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS