protein
| binding partner of syntaxin 6 (Fukuda 2006) |
|
interacting with DLG1 (anchor for the E3 ligase MARCH2 at sites of cell-cell contact) (Cao 2008) |
|
MARCH2 catalytic activity is not required for its interaction with the ADRB2 and loss of activity creates a “substrate trap” leading to a stable complex formation between the two molecules |
|
ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins GOPC and STX6 |
|
MARCH2 interacts with CFTR (cystic fibrosis transmembrane conductance regulator), promotes the ubiquitination and degradation of CFTR, and inhibits CFTR-mediated autophagy in tumor cells ( |
|
MARCH2 restricts cytosolic pools of DVL protein and reduces the need for WNT signaling in precise vertebrate head development |
|
inhibits the production and infection of HIV-1 through ligase activity-dependent envelope protein degradation and/or intracellular retention |
|
MARCHF2-mediated ERGIC3 ubiquitination is the major cause of the decrease in trafficking of ERGIC3-binding secretory proteins |
|
MARCHF2 is a novel negative regulator of IKBKG-mediated signaling upon bacterial or viral infection |
|
MARCHF2 and MARCHF3 are critical negative regulators of IL5-triggered signaling |