SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,organelle,lysosome
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basic FUNCTION
| recruits multiple substrates via transmembrane domain-mediated interactions to permit substrate ubiquitination in the face of diverse cytosolic domain sequences |
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affects the biogenesis of CD86 via ubiquitin-dependent lysosomal degradation |
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responsible for the intracellular sequestration of MHC class II molecules in dendritic cells and monocytes in response to IL10 |
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capable of autoubiquitination |
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may regulate its own expression through dimerization and autoubiquitination |
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MARCHF1 impairs cellular insulin action by degrading cell surface INSR |
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MARCHF1 expression is increased in white adipose tissue of obese humans, suggesting that MARCH1 contributes to the pathophysiology of T2D |
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MARCHF1 is a regulator of lipid metabolism and glucose tolerance, whose function is modified by sex-specific factors |
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membrane-anchored E3 ubiquitin ligase that is involved in a variety of cellular processes |
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has an important role in the development and progression of hepatocellular carcinoma |
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ubiquitin ligase MARCHF1 limits the number of MHC II-C3 complexes displayed on conventional dendritic cells (cDCs) to prevent their elimination through excessive trogocytosis |
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MARCHF1 and MARCHF8 are ubiquitin ligases that control the expression and trafficking of critical immunoreceptors |
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tissue-specific functions of MARCHF1 and MARCHF8 in regulation of immune receptor expression |