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FLASH GENE

Symbol

MARCH9

contributors: mct - updated : 28-11-2012

HGNC name	membrane-associated ring finger (C3HC4) 9
HGNC id	25139

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q14.1      Physical location : 58.148.899 - 58.153.689
Synonym symbol(s)	RNF179, FLJ36578, MARCH-IX
EC.number	6.3.2.-

DNA

TYPE	functioning gene
STRUCTURE	4.00 kb     4 Exon(s)

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Endocrine neuroendocrine pituitary     highly Hearing/Equilibrium ear inner cochlea   moderately Reproductive female system uterus     moderately Respiratory respiratory tract larynx     highly Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   moderately

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a RING-CH-type zinc finger

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to murine March9 (95.66 pc)

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION	may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies
	accepting ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates

CELLULAR PROCESS

protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

ULBP1 is a target for the MARCH family of E3 ligases, MARCH4 and MARCH9, suggesting that induction of ULBP1 in response to heat shock is due to regulated association with its E3 ligases

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS