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FLASH GENE
Symbol MARCH9 contributors: mct - updated : 28-11-2012
HGNC name membrane-associated ring finger (C3HC4) 9
HGNC id 25139
Location 12q14.1      Physical location : 58.148.899 - 58.153.689
Synonym symbol(s) RNF179, FLJ36578, MARCH-IX
EC.number 6.3.2.-
DNA
TYPE functioning gene
STRUCTURE 4.00 kb     4 Exon(s)
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Endocrineneuroendocrinepituitary  highly
Hearing/Equilibriumearinnercochlea moderately
Reproductivefemale systemuterus  moderately
Respiratoryrespiratory tractlarynx  highly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal moderately
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING-CH-type zinc finger
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine March9 (95.66 pc)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies
  • accepting ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ULBP1 is a target for the MARCH family of E3 ligases, MARCH4 and MARCH9, suggesting that induction of ULBP1 in response to heat shock is due to regulated association with its E3 ligases
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS